Table 7 and 8 summarize the common acute and long term
adverse events associated with use of ARV agents.
Acute adverse events of ARV Drugs
Taking with or after food
Mostly self Limiting Symptomatic treatment
Diffuse maculo- popular with/ without pruritus Severe reaction: With fever and
Hepatitis
or Mucus membrane Involvement(SJS
Always use NVP in lead in dose Do not double NVP rash: dose when
rash present Do not use Prophylactic Steroids/ant- histamines
Mild-moderate rash: antihistam-inesevere Distcontinue* and never re-challenge
Drowsiness, abnormal dreams, impaired concentration
Educate patient take 2-3 hrs before slee -ping Take on empty stomach
Self limiting resolve in 2-4 weeks
Nausea, anorexia vomiting Sometimes jaundice
Monitoring ALT /AST. Avoid NVP in
women
With CD4>250
& men with CD4
400 Careful
use of NVP in
HBV/HCV
co-infected
patients
Symptomatic :discontinue permanently Asymptomatic: ALT>5 times discontinue
Hypersent- Itivity reaction
Fever, rash malaise, worsens
Discontinue and never rechallengev
with continutation
of ABC
Discontinue and never rechallengev