Name
HEMOGLOBINURIA
DESCRIPTION
DETAIL
CAUSES : * - HEMOLYTIC ANEMIAS CLASSIFICATION OF HAEMOLYTIC ANEMIA 1. ABNORMALITIES OF RBC INTERIOR A. ENZYME DEFECTS LIKE - G-6PD - PYRUVATE KINASE DEFICIENCY B. HEMOGLOBINOPATHIES LIKE - SICKLE CELL ANEMIA - BETA-THALLASSAEMIA MAJOR 2. RBC MEMBRANE ABNORMALITIES A. HEREDITARY SPHEROCYTOSIS ETC B. PAROXYSMAL NOCTURNAL HEMOGLOBINURIA C. SPUR CELL ANEMIA 3. EXTRINSIC FACTORS A. HYPERSPLENISM B. ANTIBODY : IMMUNE HEMOLYSIS 1. WARM ANTIBODY IMMUNOHEMOLYTIC ANEMIA * IDIOPATHIC * LYMPHOMAS LIKE CHR LYMPHOCYTIC LEUKEMIA, NON HODGKINS LYMPHOMAS, HODGKINS DISEASE * SLE & OTHER COLLAGEN VASCULAR DISEASES * DRUGS LIKE METHYLDOPA, PENICILLIN, QUINIDINE TYPES * POST VIRAL INFECTIONS * OTHER TUMORS ( RARE ) 2. COLD ANTIBODY IMMUNOHEMOLYTIC ANEMIA * COLD AGGLUTININ DISEASE LIKE MYCOPLASMA INFECTION, INFECTIOUS MONONUCLEOSIS, IDIOPATHIC & LYMPHOMA * PAROXYSMAL COLD HEMOGLOBINURIA C. NON-IMMUNE OR MICROANGIOPATHIC HEMOLYSIS ASSOCIATED WITH FIBRIN DEPOSITION & MECHANICAL DAMAGE TO RBC D. INFECTIONS LIKE MALARIA, CLOSTRIDIUM WELCHII SEPTICAEMIA, GRAM NEGATIVE SEPTICAEMIA LEADING TO DIC * VALVE PROSTHESES * TOXINS ETC * PROLONGED RUN OR MARCH * HEMOLYTIC - UREMIC SYNDROME * EXCESSIVE BURN * ACUTE HEMOLYTIC TRANSFUSION REACTIONSOTHER TESTS : * PLASMA HEMOGLOBIN - RAISED * URINE HEMOSIDERIN , HEMOGLOBIN ( IN SEVERE CASES ) - RAISED
TYPENOTES
RELATED DISEASE
Not Available Disease
DISEASE
INVESTIGATION
RETICULOCYTE COUNT, SERUM BILIRUBIN TOTAL, SERUM BILIRUBIN DIRECT, URINE ROUTINE, URINE FOR BILE SALTS AND BILE PIGMENTS, SERUM BILIRUBIN INDIRECT, BONE MARROW ASPIRATION, COMPLETE BLOOD COUNT