Name
DYSBETALIPOPROTEINEMIA
DESCRIPTION
DETAIL
CAUSES : 1. PRIMARY CAUSE : - HOMOGYGOUS FOR APOLIPOPROTEIN E-2 - GENETIC MUTATION IN APOLIPOPROTEIN E GENE OR COMPLETE ABSENCE PF APOLIPOPROTEIN E 2. SECONDARY CAUSE : - OBESITY - DIABETES MELLITUS - HYPOTHYROIDISM - DRUGS INTAKE LIKE PROTEASE INHIBITORS WHICH CAUSE HYPERLIPIDEMIA* LIPID PROFILE - VERY HIGH S. CHOLESTROL ( 300-600 MG% ), TRIGLYCERIDES ( 400-1000 MG% ) * LIPOPROTEIN ELECTROPHORESIS, DENSITY-GRADIENT ULTRA CENTRIFUGATION & NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY CAN ALSO MEASURE VLDL & IDL LEVELS * SCREENING TEST FOR HYPOTHYROIDISM, DIABETES MELLITUS & NEPHROTIC SYNDROME FOR SECONDARY CAUSES.
TYPENOTES
First-degree relatives should be screened for hyperlipidemia and the risks of cardiovascular disease.A RARE LIPID DISORDER. Cholesterol levels usually range from 300-600 mg/dL. Triglyceride concentrations usually are greater than 400 mg/dL and may exceed 1000 mg/dL. AN ASSOCIATED DIABETES MELLITUS, OBESITY, HYPOTHYROIDISM OR ANOTHER LIPID ABNORMALITY LIKE FAMILIAL COMBINED HYPERLIPIDEMIA. MEDICAL TREATMENT : " Patients first should be treated for the metabolic condition that is causing or exacerbating their hyperlipidemia. o If diabetes is present, glucose levels and glycosylated hemoglobin (HbA1c) should be normalized if possible. o If hypothyroidism is diagnosed, TSH should be normalized. o Obesity and inactivity should be addressed appropriately. " A careful history should be obtained to find other modifiable risk factors for atherosclerosis, such as smoking and hypertension, that can be addressed. " First-degree relatives should be screened for hyperlipidemia and the risks of cardiovascular disease. Surgical Care " Surgical care is not indicated DRUG TREATMENT : 1. HYLIPIDEMIC : - GEMFIBROZIL - FENOFIBRATE - NIACIN
RELATED DISEASE
Not Available Disease
DISEASE
INVESTIGATION
BLOOD SUGAR ( FASTING ), URINE ROUTINE, TSH, COMPLETE BLOOD COUNT, LIPIDS PROFILE