Name
GROWTH HORMONE DEFICIENCY
DESCRIPTION
DETAIL
CAUSES IN CHILDREN : 1. CONGENITAL - DEFECTIVE PITUITARY DEVELOPMENT LEADING TO PITUITARY APLASIA - EMPTY SELLA - ENCEPHALOCELE - MIDLINE DEFECTS - SEPTOOPTIC DYSPLASIA - PANHYPOPITUITARISM - GENETIC ABNORMALITIES INCLUDING AUTOSOMAL RECESSIVE, AUTOSOMAL DOMINANT OR SEX LINKED DEFECTS OR A MUTATION OR DELETION IN THE GH GENE OR IN GH-RELEASING HORMONE 2. ACQUIRED CONDITIONS - TUMORS OF HYPOTHALAMIC-PITUITARY REGION - CRANIAL IRRADIATION - INFILTRATIVE DISEASES - TRAUMA - HYPOXIC INSULT - IDIOPATHIC CAUSES IN ADULTHOOD - > 90% HAVE PITUITARY DISEASE LIKE TUMOR, SURGERY, IRRADIATION, TRAUMA, INFILTRATIVE DISEASESA SERUM GROWTH HORMONE LEVEL OF < 20NG/ML IS HIGHLY SUGGESTIVE OF GH DEFICIENCY. GROWTH HORMONE STIMULATION TEST(INSULIN TOLERANCE TEST) :INSULIN IS GIVEN I.V. TO PRODUCE PLASMA GLUCOSE LEVELS OF< 40 MG%, THEN GH LEVEL IS MEASURE AFTER 20-30 MTS. GH DEFICIENCY IS CONFIRMED IF LEVELS ARE < 10 MCG/ML IN CHILDREN & <3 MCG/ML IN ADULTS. THIS SHOULD BE ON TWO TEST OCCASIONS AT LEAST. * LEVELS OF INSULINLIKE GROWTH FACTOR 1 ( IGF-1) OR IGF-BINDING PROTEIN-3 - LOW * SERUM LIPIDS ARE HIGH * MRI OF HYPOTHALAMIC-PITUITARY REGION
TYPENOTES
RELATED DISEASE
Not Available Disease
DISEASE
INVESTIGATION
GROWTH HORMONE ( MALE ), GROWTH HORMONE ( FEMALE ), GROWTH HORMONE ( CHILDREN ), COMPLETE BLOOD COUNT, LIPIDS PROFILE, MRI
[GROWTH HORMONE DEFICIENCY]