Name
TESTOTOXICOSIS
DESCRIPTION
DETAIL
A AUTOSOMAL DOMINANT, GONADOTROPIN INDEPENDENT FORM OF MALE PRECOCITY D.D. : 1. ISOSEXUAL PRECOCITY A. TRUE PRECOCIOUS PUBERTY - CONSTITUTIONAL - ORGANIC BRAIN DISEASE - CONGENITAL ADRENAL HYPERPLASIA B. PRECOCIOUS PSEUDOPUBERTY - OVARIAN TUMORS - ADRENAL TUMORS - MCCUNE-ALBRIGHT SYNDROME - HYPOTHYROIDISM - RUSSELL-SILVER SYNDROME - ESTROGEN- CONTAINING MEDICATIONS C. INCOMPLETE SEXUAL PRECOCITY - PREMATURE THELARCHE - PREMATURE ADRENARCHE - PREMATURE PUBARCHE 2. HETEROSEXUAL PRECOCITY - OVARIAN TUMORS - ADRENAL TUMORS - CONGENITAL ADRENAL HYPERPLASIA -------------------------------------------------------------------------- SECOND CLASSIFICATION OF D.D. : 1. CENTRAL ( GNRH- DEPENENT ) - IDIOPATHIC TRUE PRECOCIOUS PUBERTY - CNS TUMORS ( HAMARTOMAS, HYPOTHALAMIC TUMORS ) - CNS DISORDERS ( MENINGITIS, ENCEPHALITIS, HYDROCEPHALUS, TRAUMA, ABSCESSES, CYSTS, GRANULOMAS, RADIATION THERAPY ) 2. PERIPHERAL ( GNRH-INDEPENDENT ) A. MALES - HCG SECRETING TUMORS ( CNS , LIVER ) - CONGENITAL ADRENAL HYPERPLASIA * 21-HYDROXYLASE DEFICIENCY * 3-BETA HYDROXYSTEROID DEHYDROGENASE DEFICIENCY * 11-HYDROXYLASE DEFICIENCY - ADRENAL TUMORS - LEYDIG CELL TESTICULAR TUMORS - MC CUNE-ALBRIGHT SYNDROME ( POLYOSTOTIC FIBROUS DYSPLASIA ) B. FEMALES - FOLLICULAR CYSTS - OVARIAN TUMORS - ADRENAL TUMORS - - CONGENITAL ADRENAL HYPERPLASIA * 21-HYDROXYLASE DEFICIENCY * 3-BETA HYDROXYSTEROID DEHYDROGENASE DEFICIENCY * 11-HYDROXYLASE DEFICIENCY - EXOGENOUS ESTROGENS - MC CUNE-ALBRIGHT SYNDROME ( POLYOSTOTIC FIBROUS DYSPLASIA )* SERUM TESTOSTERONE LEVELS - HIGH * SERUM GONADOTROPIN LEVELS - LOW * GONADOTROPIN RELEASING HORMONE STIMULATION TEST - A SUPPRESSED OR PREPUBERTAL LH RESPONSE & BY ADOLESCENCE TO ADULTHOOD A MORE TYPICAL LH-PREDOMINANT PUBERTAL RESPONSE.
TYPENOTES
RELATED DISEASE
Not Available Disease
DISEASE
INVESTIGATION
SERUM TESTOSTERONE( TOTAL ) FOR FEMALE, COMPLETE BLOOD COUNT