Monograph: |
OCTENIDINE DIHYDROCHLORIDE
OCTENIDINE WAS INTRODUCED FOR SKIN, MUCOUS MEMBRANE AND WOUND ANTISEPSIS MORE THAN 20 YEARS AGO. NOWADAYS, OCTENIDINE IS AN ESTABLISHED ANTISEPTIC IN A LARGE FIELD OF APPLICATIONS AND REPRESENTS AN ALTERNATIVE TO OLDER SUBSTANCES SUCH AS CHLORHEXIDINE, POLYVIDONE-IODINE OR TRICLOSAN. IT IS ACTIVE AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA .
OCTENIDINE IS ABSORBED NEITHER THROUGH THE SKIN, NOR THROUGH MUCOUS MEMBRANES, NOR VIA WOUNDS AND DOES NOT PASS THE PLACENTAL BARRIER. HOWEVER, CATION-ACTIVE COMPOUNDS CAUSE LOCAL IRRITATION AND ARE EXTREMELY POISONOUS WHEN ADMINISTERED PARENTERALLY .[5]
IN A 2016 IN VITRO STUDY OF MOUTH RINSES ON GINGIVAL FIBROBLASTS AND EPITHELIAL CELLS OCTENIDINE SHOWED A LESS CYTOTOXIC EFFECT, ESPECIALLY ON EPITHELIAL CELLS, COMPARED TO CHLORHEXIDINE AFTER 15 MIN.[8] WOUND IRRIGATION WITH OCTENIDINE HAS CAUSED SEVERE COMPLICATIONS IN DOGS,[9] ASEPTIC NECROSIS AND CHRONIC INFLAMMATION IN PENETRATING HAND WOUNDS
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