Monograph: |
AN ISOFLAVONOID DERIVED FROM SOY PRODUCTS. IT INHIBITS PROTEIN-TYROSINE KINASE AND TOPOISOMERASE-II (DNA TOPOISOMERASES, TYPE II) ACTIVITY AND IS USED AS AN ANTINEOPLASTIC AND ANTITUMOR AGENT. EXPERIMENTALLY, IT HAS BEEN SHOWN TO INDUCE G2 PHASE ARREST IN HUMAN AND MURINE CELL LINES.
ADDITIONALLY, GENISTEIN HAS ANTIHELMINTIC ACTIVITY. IT HAS BEEN DETERMINED TO BE THE ACTIVE INGREDIENT IN FELMINGIA VESTITA, WHICH IS A PLANT TRADITIONALLY USED AGAINST WORMS. IT HAS SHOWN TO BE EFFECTIVE IN THE TREATMENT OF COMMON LIVER FLUKE, PORK TREMATODE AND POULTRY CESTODE.
FURTHER, GENISTEIN IS A PHYTOESTROGEN WHICH HAS SELECTIVE ESTROGEN RECEPTOR MODULATOR PROPERTIES. IT HAS BEEN INVESTIGATED IN CLINICAL TRIALS AS AN ALTERNATIVE TO CLASSICAL HORMONE THERAPY TO HELP PREVENT CARDIOVASCULAR DISEASE IN POSTMENOPAUSAL WOMEN .
NATURAL SOURCES OF GENISTEIN INCLUDE TOFU, FAVA BEANS, SOYBEANS, KUDZU, AND LUPIN.
PHARMACOLOGY
INDICATION
CURRENTLY GENISTEIN IS BEING STUDIED IN CLINICAL TRIALS AS A TREATMENT FOR PROSTATE CANCER.
PHARMACODYNAMICS
NOT AVAILABLE
MECHANISM OF ACTION
GENISTEIN MAY INHIBIT CANCER CELL GROWTH BY BLOCKING ENZYMES REQUIRED FOR CELL GROWTH.
GENISTEIN MAY DECREASE CARDIOVASCULAR RISK IN POSTMENOPAUSAL WOMEN BY INTERACTING WITH THE NUCLEAR ESTROGEN RECEPTORS TO ALTER THE TRANSCRIPTION OF CELL SPECIFIC GENES. IN RANDOMIZED CLINICAL TRIALS, GENISTEIN WAS SEEN TO INCREASE THE RATIO OF NITRIC OXIDE TO ENDOTHELIN AND IMPROVED FLOW-MEDIATED ENDOTHELIUM DEPENDENT VASODILATION IN HEALTHY POSTMENOPAUSAL WOMEN . IN ADDITION, GENISTEIN MAY HAVE BENEFICIAL EFFECTS ON GLUCOSE METABOLISM BY INHIBITING ISLET TYROSINE KINASE ACTIVITY AS WELL AS INSULIN RELEASE DEPENDENT ON GLUCOSE AND SULFONYLUREA
THIS COMPOUND BELONGS TO THE CLASS OF ORGANIC COMPOUNDS KNOWN AS ISOFLAVONES. THESE ARE POLYCYCLIC COMPOUNDS CONTAINING A 2-ISOFLAVENE SKELETON WHICH BEARS A KETONE GROUP AT THE C4 CARBON ATOM.
DRUG INTERACTION:
WARFARIN THE METABOLISM OF (R)-WARFARIN CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
(S)-WARFARIN THE METABOLISM OF (S)-WARFARIN CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
3,5-DIIODOTHYROPROPIONIC ACID THE THERAPEUTIC EFFICACY OF 3,5-DIIODOTHYROPROPIONIC ACID CAN BE DECREASED WHEN USED IN COMBINATION WITH GENISTEIN.
3,5-DIIODOTYROSINE THE THERAPEUTIC EFFICACY OF 3,5-DIIODOTYROSINE CAN BE DECREASED WHEN USED IN COMBINATION WITH GENISTEIN.
4-HYDROXYCOUMARIN THE METABOLISM OF 4-HYDROXYCOUMARIN CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
6-O-BENZYLGUANINE THE METABOLISM OF 6-O-BENZYLGUANINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
8-AZAGUANINE THE METABOLISM OF 8-AZAGUANINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
8-CHLOROTHEOPHYLLINE THE METABOLISM OF 8-CHLOROTHEOPHYLLINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
9-AMINOCAMPTOTHECIN THE METABOLISM OF 9-AMINOCAMPTOTHECIN CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
9-DEAZAGUANINE THE METABOLISM OF 9-DEAZAGUANINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
9-METHYLGUANINE THE METABOLISM OF 9-METHYLGUANINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ABALOPARATIDE THE THERAPEUTIC EFFICACY OF ABALOPARATIDE CAN BE DECREASED WHEN USED IN COMBINATION WITH GENISTEIN.
ABATACEPT THE METABOLISM OF GENISTEIN CAN BE INCREASED WHEN COMBINED WITH ABATACEPT.
ABEMACICLIB GENISTEIN MAY DECREASE THE EXCRETION RATE OF ABEMACICLIB WHICH COULD RESULT IN A HIGHER SERUM LEVEL.
ABIRATERONE THE SERUM CONCENTRATION OF GENISTEIN CAN BE INCREASED WHEN IT IS COMBINED WITH ABIRATERONE.
ACALABRUTINIB THE METABOLISM OF ACALABRUTINIB CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
ACEFYLLINE THE METABOLISM OF ACEFYLLINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ACENOCOUMAROL THE METABOLISM OF ACENOCOUMAROL CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
ACETAMINOPHEN THE SERUM CONCENTRATION OF ACETAMINOPHEN CAN BE INCREASED WHEN IT IS COMBINED WITH GENISTEIN.
ACETOHEXAMIDE THE METABOLISM OF ACETOHEXAMIDE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ACETYLSALICYLIC ACID THE METABOLISM OF ACETYLSALICYLIC ACID CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ACYCLOVIR THE METABOLISM OF GENISTEIN CAN BE DECREASED WHEN COMBINED WITH ACYCLOVIR.
ADALIMUMAB THE METABOLISM OF GENISTEIN CAN BE INCREASED WHEN COMBINED WITH ADALIMUMAB.
AFATINIB GENISTEIN MAY DECREASE THE EXCRETION RATE OF AFATINIB WHICH COULD RESULT IN A HIGHER SERUM LEVEL.
AFELIMOMAB THE METABOLISM OF GENISTEIN CAN BE INCREASED WHEN COMBINED WITH AFELIMOMAB.
AGOMELATINE THE METABOLISM OF AGOMELATINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ALBENDAZOLE THE METABOLISM OF GENISTEIN CAN BE DECREASED WHEN COMBINED WITH ALBENDAZOLE.
ALBINTERFERON ALFA-2B THE METABOLISM OF GENISTEIN CAN BE DECREASED WHEN COMBINED WITH ALBINTERFERON ALFA-2B.
ALECTINIB THE METABOLISM OF ALECTINIB CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
ALLOPURINOL GENISTEIN MAY DECREASE THE EXCRETION RATE OF ALLOPURINOL WHICH COULD RESULT IN A HIGHER SERUM LEVEL.
ALLYLESTRENOL THE METABOLISM OF ALLYLESTRENOL CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
ALMOTRIPTAN THE METABOLISM OF ALMOTRIPTAN CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ALOSETRON THE METABOLISM OF GENISTEIN CAN BE DECREASED WHEN COMBINED WITH ALOSETRON.
ALPELISIB THE SERUM CONCENTRATION OF ALPELISIB CAN BE INCREASED WHEN IT IS COMBINED WITH GENISTEIN.
ALPRAZOLAM THE METABOLISM OF ALPRAZOLAM CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ALVOCIDIB GENISTEIN MAY DECREASE THE EXCRETION RATE OF ALVOCIDIB WHICH COULD RESULT IN A HIGHER SERUM LEVEL.
AMBRISENTAN THE EXCRETION OF AMBRISENTAN CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
AMINOPHENAZONE THE METABOLISM OF AMINOPHENAZONE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
AMINOPHYLLINE THE METABOLISM OF AMINOPHYLLINE CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
AMIODARONE THE METABOLISM OF AMIODARONE CAN BE INCREASED WHEN COMBINED WITH GENISTEIN.
AMITRIPTYLINE THE METABOLISM OF AMITRIPTYLINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
AMODIAQUINE THE METABOLISM OF AMODIAQUINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
AMPRENAVIR THE METABOLISM OF AMPRENAVIR CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ANAGRELIDE THE METABOLISM OF GENISTEIN CAN BE DECREASED WHEN COMBINED WITH ANAGRELIDE.
ANAKINRA THE METABOLISM OF GENISTEIN CAN BE INCREASED WHEN COMBINED WITH ANAKINRA.
ANASTROZOLE THE METABOLISM OF ANASTROZOLE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
ANTIPYRINE THE METABOLISM OF ANTIPYRINE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN.
APALUTAMIDE THE METABOLISM OF APALUTAMIDE CAN BE DECREASED WHEN COMBINED WITH GENISTEIN
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