Monograph: |
LACTASE ENZYME
DESCRIPTION
TILACTASE IS A BETA-D-GALACTOSIDASE OBTAINED FROM ASPERGILLUS ORYZAE. IT IS PRODUCED AS A CHEWABLE TABLET THAT HAS TO BE TAKEN BEFORE THE CONSUMPTION OF A LACTOSE-CONTAINING MEAL. THE BETA-D-GALACTOSIDASE US A LARGE MONOMERIC MULTI-DOMAIN ENZYME OF 985 RESIDUES THAT PRESENTS A CATALYTIC (ALPHA/BETA)8-BARREL DOMAIN. IT IS CONSIDERED BY THE WHO AS PART OF THE INTERNATIONAL NONPROPIETARY NAMES FOR PHARMACEUTICAL SUBSTANCES.
SYNONYMS
路 BETA-D-GALACTOSIDASE
路 BETA-GALACTOSIDASE
路 LACTASE
路 TILACTASA
路 TILACTASE
路 TILACTASUM
PHARMACOLOGY
INDICATION
TILACTASE IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF LACTOSE INTOLERANCE IN INFANTS AND OLDER PATIENTS REQUIRING A PARENTERAL NUTRITION OR FLUID DIET.
LACTOSE INTOLERANCE OCCURS WHEN THERE IS AN EXISTENCE OF AN INABILITY TO BREAK DOWN LACTOSE WHICH IS COMMONLY FOUND IN DAIRY PRODUCTS. THIS INABILITY OCCURS WHEN THE LACTASE LEVELS ARE REDUCED AND THUS THERE IS NO VIA TO DIGEST AND BREAK DOWN THE LACTOSE. THE UNDIGESTED LACTOSE MOVES INTO THE LARGE INTESTINE WHERE NORMAL FLORA BACTERIA CAN INTERACT WITH IT AND CAUSE BLOATING, GAS AND DIARRHEA.
ASSOCIATED CONDITIONS
路 LACTOSE INTOLERANCE
PHARMACODYNAMICS
THE USE OF A SINGLE ORAL ADMINISTRATION OF TILACTASE HAS BEEN SHOWN TO BE HIGHLY EFFECTIVE IN DECREASING THE SYMPTOMS AND HYDROGEN EXCRETION OF HYPOLACTASIA IN TESTS OF LACTOSE H(2)-BREATH. THE ANALYSIS HAS SHOWN A DECREASE OF APPROXIMATELY 80% IN BOTH MALABSORBERS AND INTOLERANTS.THE ADMINISTRATION OF TILACATASE ALSO DECREASES THE PRESENCE OF BLOATING AND FLATUS.
MECHANISM OF ACTION
LACTOSE IS THE PRIMARY DISACCHARIDE FOUND IN DAIRY PRODUCTS. TILACTASE IS A TYPE OF LACTASE WHICH IS THE ENZYME THAT IS IN CHARGE OF THE BREAKDOWN OF LACTOSE TO GLUCOSE AND GALACTOSE WHICH CAN BE USED BY THE BODY. BASICALLY, TILACTASE ACTS BY REPLACING THE MISSING LACTASE IN THE BODY AND ALLOWS AVOIDANCE OF THE REACH OF LACTOSE TO THE SMALL INTESTINE AND THE NORMAL BACTERIA AND THUS, PREVENTING THE SYMPTOMS OF THE LACTOSE INTOLERANCE. ONCE TILACTASE HAS METABOLIZED THE LACTOSE, THE METABOLISM PRODUCTS ARE REABSORBED BY THE NORMAL PROCESS OF DIGESTION.
ABSORPTION
TILACTASE IS NOT ABSORBED IN THE GI TRACT AND THUS THE PHARMACOKINETIC PARAMETERS RELATED TO ABSORPTION ARE NOT RELEVANT.
VOLUME OF DISTRIBUTION
TILACTASE IS NOT ABSORBED AND THUS THE VOLUME OF DISTRIBUTION IS NOT RELEVANT.
PROTEIN BINDING
TILACTASE IS NOT ABSORBED AND THUS THE PLASMA PROTEIN BINDING IS NOT POSSIBLE.
METABOLISM
TILACTASE IS DEGRADED BY THE STOMACH ACID AND BY THE NORMAL FLORA BACTERIAL METABOLISM.
ROUTE OF ELIMINATION
TILACTASE IS COMPLETELY ELIMINATED IN THE FECES EITHER UNCHANGED OR AS METABOLITES.
HALF LIFE
TILACTASE HALF-LIFE AT 35潞C IS REGISTERED TO BE 123.77 MIN. THIS HALF-LIFE CAN BE AFFECTED BY TEMPERATURE IN AN INVERSELY PROPORTIONAL MANNER.
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