Monograph: |
BALOFLOXACIN
Balofloxacin is a fluoroquinolone that has a broader spectrum of activity and reduced toxicity than other fluoroquinolones. Pharmacodynamics : The bactericidal action of Balofloxacin results from interference with the enqyme DNA gyrase which is needed for the synthesis of bacterial DNA. Balofloxacin is efficacious against Gram-negative bacteria. It also has enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae. Pharmacokinetics: Balofloxacin appears well-absorbed after oral doses. One hour after oral doses of 200mg in patients with chronic prostatitis, the mean level in prostatic fluid was 0.34 mcg/mL; the corresponding serum level was 0.78mcg/mL. Steady-state volume of distribution in healthy subjects after 200mg doses is 38L. Urinary excretions data suggest minimal hepatic metabolism. Elimination half-life is 7 to 8 hours.
INDICATIONS : Treatment of Uncomplicated urinary tract infectins.
CONTRAINDICATIONS : History of hypersensitivity to the drug, pregnant women and nursing mother, children and infants.
SAFETY PROFILE :Care should be exercised in patients with severe renal failure, hypersensitivity to quinolones. Discontinue the drug if shock symptoms may occur. elevations in GOT, GPT, LDH & AL-P level and jaundice may occur rarely in these cases. Therapy should be discontinued if symptoms occur and appropriate treatment to be initiated. Hyperglycemia after other quinolones dosing where reported. Should not be given during pregnancy, lactating mothers & children unless it is really essential.
ADVERSE EFFECTS :Nausea, Heartburn, Dizziness, Fever, Indigestion, Urticaria,
DRUG INTERACTIONS : Administration of quinolones with antacids containing magnesium or aluminium interfere with the absorption of quinolones. The agent should not be taken with at once. The concomitant administration of non-steroidal anti-inflammatory drug with quinolone and increase the risk of convulsive seizures. The concomitant administration of other quinolones with theophylline has elevated serum theophylline levels. Therefore the theophylline dosage should be decreased when quinolones is co-administred
DOSAGE :100mg twice daily.
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