Monograph: |
Benperidol
A white or almost white powder. It exhibits polymorphism. Practically insoluble in water; slightly soluble in alcohol; soluble in dichloromethane; freely soluble in dimethylformamide. Protect from light.
Drug Profile
Benperidol is a butyrophenone with general properties similar to those of haloperidol. Doses of 0.25 to 1.5 mg daily in divided doses are given by mouth in the management of deviant sexual behaviour. Elderly or debilitated patients may require reduced doses.
In some countries benperidol is given by mouth or parenterally for the treatment of psychotic conditions.
Dose
0.25-1.5 mg daily in divided doses, adjusted according to response; elderly (or debilitated) initially half adult dose; child not recommended
Deviant sexual behaviour.
Results of a double-blind placebo-controlled crossover study demonstrated no difference between the effect of benperidol 1.25 mg daily, chlorpromazine 125 mg daily, or placebo on sexual drive and arousal in 12 paedophilic sexual offenders, except for a lower frequency of sexual thoughts with benperidol. The effects of benperidol are unlikely to be sufficient to control severe forms of antisocial sexually deviant behaviour.
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