Monograph: |
Mecysteine hydrochloride
Adverse Effects and Precautions
Nausea and heartburn have occasionally been reported. Since mucolytics may disrupt the gastric mucosal barrier mecysteine hydrochloride should be used with caution in patients with a history of peptic ulcer disease.
Uses and Administration
Mecysteine hydrochloride is used as a mucolytic in respiratory disorders associated with productive cough. It is given by mouth in a usual dose of 200 mg three times daily before meals reduced to 200 mg twice daily after 6 weeks. A rapid clinical effect can be achieved by giving 200 mg four times daily for the first 2 days. Children over 5 years of age may be given 100 mg three times daily. It has also been given by inhalation.
Respiratory disorders.
Mecysteine hydrochloride given by mouth has reduced symptoms of cough in patients with chronic bronchitis or other respiratory disorders, but its effect on sputum production and pulmonary function has been variable. The use of mucolytics in chronic obstructive pulmonary disease is controversial.
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