CONCOMITANT ADMINISTRATION OF ANTIMUSCARINICS, ANTACIDS, HISTAMINE H2 ANTAGONISTS, AND PROTON PUMP INHIBITORS, MAY REDUCE STAMACH ACIDITY AND ABSORPTION OF ECONAZOLE. COMCOMITANT ADMINISTRATION OF ECONAZOLE WITH ENZYME-INDUCING DRUGS SUCH AS RIFAMPICIN, ISONIAZID, OR PHENYTOIN MAY REDUCE PLASMA CONCENTRATIONS OF ECONAZOLE. ANTAGONISM WITH POLYENE ANTIBIOTICS.
ECONAZOLE USED COMCOMITANTLY WITH ASTEMIZOLE, CISAPRIDE, OR TERFENADINE THERE IS A RISK OF CARDIAC ARRHYTHMIAS.