MALARIA :- 25 MG/KG/BODY WT. GIVEN OVER 3 DAYS.
THE ADULT DOSAGE REGIMEN FOR CHLOROQUINE(2) BY MOUTH IS:
INITIAL DOSE OF 600 MG (OF BASE) THEN
A SINGLE DOSE OF 300 MG AFTER 6 TO 8 HOURS THEN
A SINGLE DOSE OF 300 MG DAILY FOR 2 DAYS
(APPROXIMATE TOTAL CUMULATIVE DOSE OF 25 MG/KG OF BASE)
CHLOROQUINE ALONE IS ADEQUATE FOR P. MALARIAE INFECTIONS BUT IN THE CASE OF P. VIVAX AND P. OVALE, A RADICAL CURE (TO DESTROY PARASITES IN THE LIVER AND THUS PREVENT RELAPSES) IS REQUIRED. THIS IS ACHIEVED WITH PRIMAQUINE(3) GIVEN AFTER CHLOROQUINE; IN P. VIVAX INFECTION PRIMAQUINE IS GIVEN IN AN ADULT DOSAGE OF 30 MG DAILY FOR 14 DAYS AND FOR P. OVALE INFECTION IT IS GIVEN IN AN ADULT DOSAGE OF 15 MG DAILY FOR 14 DAYS.
CHILDREN
THE DOSAGE REGIMEN OF CHLOROQUINE(2) FOR BENIGN MALARIA IN CHILDREN IS:
INITIAL DOSE OF 10 MG/KG (OF BASE) THEN
A SINGLE DOSE OF 5 MG/KG AFTER 6 - 8 HOURS THEN
A SINGLE DOSE OF 5 MG/KG DAILY FOR 2 DAYS
FOR A RADICAL CURE, CHILDREN ARE THEN GIVEN PRIMAQUINE(3); IN P. VIVAX INFECTION PRIMAQUINE IS GIVEN IN A DOSE OF 500 MICROGRAMS/KG DAILY FOR 14 DAYS, AND FOR P. OVALE INFECTION IT IS GIVEN IN A DOSE OF 250 MICROGRAMS/KG DAILY FOR 14 DAYS.
HEPATIC AMOEBIASIS :- 600 MG DAILY FOR 2 DAYS THEN 300 MG DAILY FOR 2 OR 3 WEEKS.
CHILDREN :- 6 MG/KG DAILY UP TO A MAX. 300 MG.
PREGNANCY :
THE ADULT TREATMENT DOSES OF CHLOROQUINE CAN BE GIVEN FOR BENIGN MALARIA. IN THE CASE OF P. VIVAX OR P. OVALE, HOWEVER, THE RADICAL CURE WITH PRIMAQUINE SHOULD BE POSTPONED UNTIL THE PREGNANCY IS OVER; INSTEAD CHLOROQUINE SHOULD BE CONTINUED AT A DOSE OF 300 MG EACH WEEK DURING THE PREGNANCY.
PROPHYLAXIS OF MALARIA, PREFERABLY STARTED 1 WEEK BEFORE ENTERING ENDEMIC AREA AND CONTINUED FOR 4 WEEKS AFTER LEAVING (SEE NOTES ABOVE), 300 MG ONCE WEEKLY; INFANT UP TO 12 WEEKS BODY-WEIGHT UNDER 6 KG, 37.5 MG ONCE WEEKLY; 12 WEEKS - 11 MONTHS BODY-WEIGHT 6 - 10 KG, 75 MG ONCE WEEKLY; CHILD 1 - 3 YEARS BODY-WEIGHT 10 - 16 KG, 112.5 MG ONCE WEEKLY; 4 - 7 YEARS BODY-WEIGHT 16 - 25 KG, 150 MG ONCE WEEKLY; 8 - 12 YEARS BODY-WEIGHT 25 - 45 KG, 225 MG ONCE WEEKLY; OVER 13 YEARS BODY-WEIGHT OVER 45 KG, ADULT DOSE
AS IV INFUSION - INITIAL DOSE OF 10 MG/KG BY SLOW IV INFUSION OVER A PERIOD OF NOT LESS THAN 8 HRS. FOLLOWED BY 5 MG/KG EVERY 8 HRS. UNTIL A TOTAL DOSE OF 25 MG/KG HAS BEEN GIVEN.