CIMETIDINE, FLUOXETINE, FLUVOXAMINE, KETOCONAZOLE, ITRACONAZOLE,ISONIAZID, DEXTROPROPOXYPHENE,DILTIAZEM, ERYTHROMYCIN, CLARITHROMYCIN, REDUCE THE CLEARANCE HENCE DOSE SHOULD BE REDUCED TO ONE THIRD. IT ENHANCES ACTION OF IMIPRAMINE,DESIPRAMINE & OTHER ANTIDEPRESSANTS. FLUVOXAMINE INCREASES ITS PLASMA CONCENTRATION WHEN USED TOGETHER. BUT PLASMA CONCENTRATIONS OF DIAZEPAM'S ACTIVE METABOLITE DESMETHYIDIAZEPAM ARE REDUCED AND IT IS CONSIDERED
THAT THE OVERALL EFFECT IS LIKELY TO BE MINOR. POTENTIATES ACTION OF ALCOHOL,ANTIPSYCHOTICS, ANTIHISTAMINES, GENERAL ANAESTHETICS, HYPNOTICS, SEDATIVES, OPIOID ANALGESICS AND OTHER CNS DEPRESSANTS. ORAL CONTRACEPTIVES INCREASED ITS PLASMA CONC BY 18%.PRETREATMENT WITH PETHIDINE & MORPHINE DECREASE THE RATE OF ORAL ABSOPTION OF DIAZEPAM. KETOTIFEN POTENTIATES ITS SEDATIVE EFFECT. RIFAMPICIN HAS DECREASED THE HALF-LIFE OF DIAZEPAM. WHILE ETHAMBUTOL
HAS NO EFFECT ON DIAZEPAM PHARMACOKINETICS. IN PATIENTS RE-
CEIVING THERAPY FOR TUBERCULOSIS WITH A COMBINATION OF ISONI-
AZID, RIFAMPICIN AND ETHAMBUTOL THE HALF-LIFE OF A SINGLE
DIAZEPAM DOSE WAS SHORTENED AND ITS CLEARANCE INCREASED. CARBAMAZEPINE, PHENYTOIN, PHENOBARBITONE MAY INCREASE ITS METABOLISM. SODIUM VALPROATE HAS BEEN REPORTED TO DISPLACE DIAZEPAM FROM PLASMA-PROTEIN BINDING SITES. DELAVIRDINE AND HIV-PROTEASE INHIBITDRS SUCH AS INDINAVIR, NELFINAVIR, AND RITONAVIR MAY INHIBIT THE HEPATIC MICROSOMAL SYSTEMS INVOLVED IN THE METABOLISM OF SOME BENZO-
DIAZEPINES. CHRONIC TREATMENT WITH DISULFIRAM CAN INHIBIT THE
METABOLISM OF CHLORDIAZEPOXIDE AND DIAZEPAM LEADING TO A
PROLONGED HALF-LIFE AND REDUCED CLEARANCE. CISAPRIDE & METOCLOPRAMIDE ENHANCE ITS ABSOPTION DUE TO INCREASED GUT MOTILITY. THERE ARE REPORTS OF AMINOPHYLLINE GIVEN INTRAVENOUSLY REVERSING THE SEDATION FROM INTRAVENOUS DIAZEPAM.