DURING THE COAGULATION PROCESS, THROMBIN CLEAVES THE A? AND B? CHAINS RELEASING FIBRINOPEPTIDES A AND B (FPA AND FPB, RESPECTIVELY).2 FPA IS SEPARATED RAPIDLY AND THE REMAINING MOLECULE IS A SOLUBLE FIBRIN MONOMER (FIBRIN I). THE SLOWER REMOVAL OF FPB RESULTS IN FORMATION OF FIBRIN II THAT IS CAPABLE OF POLYMERIZATION THAT OCCURS BY AGGREGATION OF FIBRIN MONOMERS.2 THE RESULTING FBRIN IS STABILIZED IN THE PRESENCE OF CALCIUM IONS AND BY ACTIVATED FACTOR XIII, WHICH ACTS AS A TRANSGLUTAMINASE. FACTOR XIIIA-INDUCED CROSS-LINKING OF FIBRIN POLYMERS RENDERS THE FIBRIN CLOT MORE ELASTIC AND MORE RESISTANT TO FIBRINOLYSIS.3 CROSS-LINKED FIBRIN IS THE END RESULT OF THE COAGULATION CASCADE, AND PROVIDES TENSILE STRENGTH TO A PRIMARY HEMOSTATIC PLATELET PLUG AND STRUCTURE TO THE VESSEL WALL.