PEGLOTICASE) IS A URIC ACID SPECIFIC ENZYME WHICH IS A PEGYLATED PRODUCT THAT CONSISTS OF RECOMBINANT MODIFIED MAMMALIAN URATE OXIDASE (URICASE) PRODUCED BY A GENETICALLY MODIFIED STRAIN OF ESCHERICHIA COLI. IT ACHIEVES ITS THERAPEUTIC EFFECT BY CATALYZING THE OXIDATION OF URIC ACID TO ALLANTOIN, THEREBY LOWERING SERUM URIC ACID. ALLANTOIN IS AN INERT AND WATER SOLUBLE PURINE METABOLITE. IT IS READILY ELIMINATED, PRIMARILY BY RENAL EXCRETION.