THE EXACT MECHANISM OF ACTION OF OXACEPROL IS NOT KNOWN. IT AFFECTS CONNECTIVE TISSUE METABOLISM AND HAS BEEN USED IN DERMATOLOGY, TO PROMOTE WOUND HEALING, AND IN RHEUMATIC DISORDERS. EXPERIMENTAL MODELS OF ARTHRITIS SHOWED THAT OXACEPROL REDUCED LEUKOCYTE EXTRAVASATION, AS WELL AS THE ADHESION OF LEUKOCYTES TO CAPILLARIES. IN VITRO STUDIES HAVE SHOWN THAT OXACEPROL STIMULATES THE UPTAKE OF 3H-GLUCOSAMINE AND 3H-PROLINE IN CHONDROCYTES AND THE INCORPORATION OF 3H-PROLINE IN THE MACROMOLECULAR STRUCTURE OF THE MATRIX OF CARTILAGE; WHICH WOULD BE RESPONSIBLE FOR THE ACTIVITY ON REGENERATING TISSUE.
ABSORPTION: 3.5 HR AFTER ORAL ADMIN.
DISTRIBUTION: PERMEATES INTO THE SYNOVIAL FLUID. BIO-AVAILABILITY AFTER ORAL ADMIN: APPROX 30%.
EXCRETION: VIA URINE (EXCLUSIVELY, UNCHANGED AND COMPLETE). ELIMINATION HALF-LIFE: 2.2 HR.