TERIFLUNOMIDE IS AN INHIBITOR OF CYP2C8 THEREFORE CONCOMITANT USE OF DRUGS METABOLIZED BY CYP2C8, SUCH AS REPAGLINIDE, PACLITAXEL, PIOGLITAZONE, OR ROSIGLITAZONE MAY HAVE INCREASED PLASMA LEVELS. TERIFLUNOMIDE DECREASES EFFECT OF WARFARIN..
TERIFLUNOMIDE, A WEAK INDUCER OF CYP1A2 SO CO-ADMINISTRATION OF DRUGS METABOLIZED BY CYP1A2 (SUCH AS DULOXETINE, ALOSETRON, THEOPHYLLINE, AND TIZANIDINE) MAY HAVE LOWER PLASMA CONCENTRATION.