IT ACTS AS A POTENT ANTIOXIDANT AND STRONGLY SCAVENGES FREE RADICALS, PROTECTING AGAINST OXIDATIVE STRESS AND NEURONAL APOPTOSIS. EDARAVONE HAS BEEN SHOWN TO ATTENUATE METHAMPHETAMINE- AND 6-OHDA-INDUCED DOPAMINERGIC NEUROTOXICITY IN THE STRIATUM AND SUBSTANTIA NIGRA, AND DOES NOT AFFECT METHAMPHETAMINE-INDUCED DOPAMINE RELEASE OR HYPERTHERMIA.[5][6] IT HAS ALSO BEEN DEMONSTRATED TO PROTECT AGAINST MPTP-MEDIATED DOPAMINERGIC NEUROTOXICITY TO THE SUBSTANTIA NIGRA, THOUGH NOTABLY NOT TO THE STRIATUM.