BRADYKININ IS A PRIMARY MEDIATOR OF PAIN & INFLAMMATION, ACTING BOTH AS A POTENT & DIRECT ACTIVATOR OF NOCICEPTORS, AND AS AN INDUCER OF PROLONGED INFLAMMATORY HYPERALGESIA. BRADYKININ IS GENERATED IN THE EXERCISING MUSCLE & CAUSES EXCITATION OF NOCICEPTORS IN THE SKELETAL MUSCLES. ZALTOPROFEN HAS POWERFUL ANALGESIA WITH TARGET ACTION ON COX & BRADYKININ PATHWAYS.