FOR INTRAVENOUS USE:
· PREPARE 2 SYRINGES WITH 3.0 ML NORMAL SALINE, USP FOR PRE- AND POST-ADMINISTRATION FLUSH.
· PRIME THE WINGED INFUSION SET WITH 3.0 ML SALINE AND INSERT THE SET INTO THE VEIN.
· ATTACH THE AMEVIVE®-FILLED SYRINGE TO THE INFUSION SET AND ADMINISTER THE SOLUTION OVER NO MORE THAN 5 SECONDS.
FOR INTRAMUSCULAR USE, INJECT THE FULL 0.5 ML OF SOLUTION. ROTATE INJECTION SITES SO THAT A DIFFERENT SITE IS USED FOR EACH NEW INJECTION. NEW INJECTIONS SHOULD BE GIVEN AT LEAST 1 INCH FROM AN OLD SITE AND NEVER INTO AREAS WHERE THE SKIN IS TENDER, BRUISED, RED, OR HARD.
THE RECOMMENDED DOSE OF AMEVIVE IS 15 MG GIVEN ONCE WEEKLY AS AN INTRAMUSCULAR (IM) INJECTION. THE RECOMMENDED REGIMEN IS A COURSE OF 12 WEEKLY INJECTIONS. RETREATMENT WITH AN ADDITIONAL 12-WEEK COURSE MAY BE INITIATED PROVIDED THAT CD4+ T LYMPHOCYTE COUNTS ARE WITHIN THE NORMAL RANGE, AND A MINIMUM OF A 12-WEEK INTERVAL HAS PASSED SINCE THE PREVIOUS COURSE OF TREATMENT.