CAROTID OR VERTEBRAL ARTERIES:
DOSAGE AND ADMINISTRATION: IOVERSOL 240, IOVERSOL 300 OR IOVERSOL 320 IS RECOMMENDED FOR THIS PROCEDURE. THE USUAL INDIVIDUAL INJECTION FOR VISUALIZATION OF THE CAROTID OR VERTEBRAL ARTERIES IS 2 TO 12 ML, REPEATED AS NECESSARY. AORTIC ARCH INJECTION FOR A SIMULTANEOUS FOUR VESSEL STUDY REQUIRES 20 TO 50 ML. TOTAL PROCEDURAL DOSES SHOULD NOT USUALLY EXCEED 200 ML.
PERIPHERAL ARTERIOGRAPHY:
DOSAGE AND ADMINISTRATION: THE USUAL INDIVIDUAL INJECTION VOLUMES FOR VISUALIZATION OF VARIOUS PERIPHERAL ARTERIES ARE AS FOLLOWS:
AORTA-ILIAC RUNOFF - 60 ML (RANGE 20 TO 90 ML)
COMMON ILIAC, FEMORAL - 40 ML (RANGE 10 TO 50 ML)
SUBCLAVIAN, BRACHIAL - 20 ML (RANGE 15 TO 30 ML)
THESE DOSES MAY BE REPEATED AS NECESSARY. TOTAL PROCEDURAL DOSES SHOULD NOT USUALLY EXCEED 250 ML.
VISCERAL AND RENAL ARTERIOGRAPHY AND AORTOGRAPHY:
DOSAGE AND ADMINISTRATION: IOVERSOL 320 IS RECOMMENDED. THE USUAL INDIVIDUAL INJECTION VOLUMES FOR VISUALIZATION FOR THE AORTA AND VARIOUS VISCERAL ARTERIES ARE AS FOLLOWS:
AORTA - 45 ML (RANGE 10 TO 80 ML)
CELIAC - 45 ML (RANGE 12 TO 60 ML)
SUPERIOR MESENTERIC - 45 ML (RANGE 15 TO 60 ML)
RENAL OR INFERIOR MESENTERIC - 9 ML (RANGE 6 TO 15 ML)
THESE DOSES MAY BE REPEATED AS NECESSARY. TOTAL PROCEDURAL DOSES SHOULD NOT USUALLY EXCEED 250 ML.
CORONARY ARTERIOGRAPHY AND LEFT VENTRICULOGRAPHY:
DOSAGE AND ADMINISTRATION: IOVERSOL 320 OR IOVERSOL 350 IS RECOMMENDED FOR THIS PROCEDURE. THE USUAL INDIVIDUAL INJECTION VOLUMES FOR VISUALIZATION OF THE CORONARY ARTERIES AND LEFT VENTRICLE ARE:
LEFT CORONARY - 8 ML (RANGE 2 TO 10 ML)
RIGHT CORONARY - 6 ML (RANGE 1 TO 10 ML)
LEFT VENTRICLE - 40 ML (RANGE 30 TO 50 ML)
THESE DOSES MAY BE REPEATED AS NECESSARY. TOTAL PROCEDURAL DOSE FOR THE COMBINED PROCEDURES SHOULD NOT USUALLY EXCEED 250 ML. WHEN LARGE INDIVIDUAL VOLUMES ARE ADMINISTERED, AS IN VENTRICULOGRAPHY AND AORTOGRAPHY, IT HAS BEEN SUGGESTED THAT SEVERAL MINUTES BE PERMITTED TO ELAPSE BETWEEN EACH INJECTION TO ALLOW FOR SUBSIDENCE OF POSSIBLE HEMODYNAMIC DISTURBANCES.
PEDIATRIC ANGIOCARDIOGRAPHY:
DOSAGE AND ADMINISTRATION: IOVERSOL 160 IS RECOMMENDED. AS A GENERAL RULE, THE VOLUME AND CONCENTRATION USED FOR IA-DSA IS ABOUT 50%, OR LESS, OF THAT USED FOR CONVENTIONAL PROCEDURES. THE ACTUAL DOSAGE AND FLOW RATE WILL VARY DEPENDING ON THE SELECTIVITY OF THE INJECTION SITE AND THE AREA BEING EXAMINED.
THE FOLLOWING SUGGESTED VOLUMES PER INJECTION ARE INTENDED ONLY AS A GUIDE. INJECTIONS MAY BE REPEATED AS NECESSARY. IT IS ADVISABLE TO INJECT AT RATES APPROXIMATELY EQUAL TO THE FLOW OF THE VESSEL BEING INJECTED.
CAROTID ARTERIES..............6 TO 10 ML
VERTEBRAL ARTERIES.............4 TO 8 ML
AORTA..........................25 TO 50 ML
SUBCLAVIAN OR BRACHIAL ARTERIES............2 TO 10 ML
MAJOR BRANCHES OF THE ABDOMINAL AORTA.............2 TO 20 ML
DOSAGE SHOULD NOT USUALLY EXCEED 250 ML.
VENOGRAPHY:
DOSAGE AND ADMINISTRATION: IOVERSOL 240, IOVERSOL 300, IOVERSOL 320 OR IOVERSOL 350 IS RECOMMENDED FOR THIS PROCEDURE. THE USUAL DOSE IS 50 TO 100 ML PER EXTREMITY WITH SMALLER OR LARGER VOLUMES INDICATED IN SOME CASES. DOSAGE SHOULD NOT USUALLY EXCEED 250 ML.
FOLLOWING THE PROCEDURE, THE VENOUS SYSTEM SHOULD BE FLUSHED WITH SODIUM CHLORIDE INJECTION U.S.P. OR 5% DEXTROSE IN WATER (D5W). MASSAGE AND ELEVATION ARE ALSO HELPFUL FOR CLEARING THE CONTRAST MEDIUM FROM THE EXTREMITY.
COMPUTED TOMOGRAPHY:
IOVERSOL 350, IOVERSOL 320, IOVERSOL 300 OR IOVERSOL 240 IS RECOMMENDED FOR HEAD IMAGING.
IOVERSOL 350, IOVERSOL 320, IOVERSOL 300 OR IOVERSOL 240 IS RECOMMENDED FOR BODY IMAGING.
HEAD IMAGING:
DOSAGE AND ADMINISTRATION:
ADULTS: THE USUAL DOSAGE IS 50 TO 150 ML OF IOVERSOL 350, IOVERSOL 320 OR IOVERSOL 300 OR 100 TO 250 ML OF IOVERSOL 240. SCANNING MAY BE PERFORMED IMMEDIATELY AFTER COMPLETION OF THE INTRAVENOUS ADMINISTRATION. DOSAGE SHOULD NOT USUALLY EXCEED 150 ML OF IOVERSOL 350, IOVERSOL 320 OR IOVERSOL 300 OR 250 ML OF IOVERSOL 240.
CHILDREN: THE DOSAGE RECOMMENDED FOR USE IN CHILDREN IS 1 ML/KG TO 3 ML/KG OF IOVERSOL 320.
BODY IMAGING:
DOSAGE AND ADMINISTRATION:
ADULTS: IOVERSOL 350, IOVERSOL 320, IOVERSOL 300 OR IOVERSOL 240 MAY BE ADMINISTERED BY BOLUS INJECTION, BY RAPID INFUSION, OR BY A COMBINATION OF BOTH. THE USUAL DOSES ARE SUMMARIZED BELOW:
BRAND BOLUS INJ. INFUSION
IOVERSOL 350 25 TO 75 ML 50 TO 150 ML
IOVERSOL 320 25 TO 75 ML 50 TO 150 ML
IOVERSOL 300 25 TO 75 ML 50 TO 150 ML
IOVERSOL 240 35 TO 100 ML 70 TO 200 ML
DOSAGE SHOULD NOT USUALLY EXCEED 150 ML OF IOVERSOL 350, IOVERSOL 320 OR IOVERSOL 300 OR 250 ML OF IOVERSOL 240.
CHILDREN: THE DOSAGE RECOMMENDED FOR USE IN CHILDREN IS 1 ML/KG TO 3 ML/KG OF IOVERSOL 320, WITH A USUAL DOSE OF 2 ML/KG.
INTRAVENOUS UROGRAPHY:
DOSAGE AND ADMINISTRATION: IOVERSOL 350, IOVERSOL 320, IOVERSOL 300 OR IOVERSOL 240 IS RECOMMENDED FOR ROUTINE AND HIGH DOSE EXCRETORY UROGRAPHY.
ADULTS: THE USUAL DOSE FOR ROUTINE EXCRETORY UROGRAPHY IN ADULTS IS 50 TO 75 ML OF IOVERSOL 350, IOVERSOL 320 OR IOVERSOL 300 OR 75 TO 100 ML OF IOVERSOL 240. HIGHER DOSAGES MAY BE INDICATED TO ACHIEVE OPTIMUM RESULTS WHERE POOR VISUALIZATION IS ANTICIPATED (E.G., ELDERLY PATIENTS OR PATIENTS WITH IMPAIRED RENAL FUNCTION). IN THESE PATIENTS, HIGH DOSE UROGRAPHY MAY BE PREFERRED, USING IOVERSOL 350 AT A DOSE OF 1.4 ML/KG (MAXIMUM 140 ML), IOVERSOL 320 AT A DOSE OF 1.5 TO 2 ML/KG (MAXIMUM 150 ML), IOVERSOL 300 AT A DOSE OF 1.6 ML/KG (MAXIMUM 150 ML) OR IOVERSOL 240 AT A DOSE OF 2 ML/KG (MAXIMUM 200 ML).
CHILDREN: IOVERSOL 320 AT DOSES OF 0.5 ML/KG TO 3 ML/KG OF BODY WEIGHT HAS PRODUCED DIAGNOSTIC OPACIFICATION OF THE EXCRETORY TRACT. THE USUAL DOSE FOR CHILDREN IS 1 ML/KG TO 1.5 ML/KG. DOSAGE FOR INFANTS AND CHILDREN SHOULD BE ADMINISTERED IN PROPORTION TO AGE AND BODY WEIGHT. THE TOTAL ADMINISTERED DOSE SHOULD NOT EXCEED 3 ML/KG.