SINCALIDE MAY BE USED:
(1) TO STIMULATE GALLBLADDER CONTRACTION, AS MAY BE ASSESSED BY CONTRAST AGENT CHOLECYSTOGRAPHY OR ULTRASONOGRAPHY, OR TO OBTAIN BY DUODENAL ASPIRATION A SAMPLE OF CONCENTRATED BILE FOR ANALYSIS OF CHOLESTEROL, BILE SALTS, PHOSPHOLIPIDS, AND CRYSTALS
FOR PROMPT CONTRACTION OF THE GALLBLADDER, A DOSE OF 0.02 MCG SINCALLDE PER KG (1.4 MCG/70 KG) IS INJECTED INTRAVENOUSLY OVER A 30- TO 60-SECOND INTERVAL; IF SATISFACTORY CONTRACTION OF THE GALLBLADDER DOES NOT OCCUR IN 15 MINUTES, A SECOND DOSE, 0.04 MCG SINCALIDE PER KG, MAY BE ADMINISTERED. TO REDUCE THE INTESTINAL SIDE EFFECTS, AN INTRAVENOUS INFUSION MAY BE PREPARED AT A DOSE OF 0.12 MCG/KG IN 100 ML OF SODIUM CHLORIDE INJECTION USP AND GIVEN AT A RATE OF 2 ML PER MINUTE; ALTERNATIVELY, AN INTRAMUSCULAR DOSE OF 0.1 MCG/KG MAY BE GIVEN. WHEN SINCALIDE IS USED IN CHOLECYSTOGRAPHY, ROENTGENOGRAMS ARE USUALLY TAKEN AT FIVE-MINUTE INTERVALS AFTER THE INJECTION. FOR VISUALIZATION OF THE CYSTIC DUCT, IT MAY BE NECESSARY TO TAKE ROENTGENOGRAMS AT ONE-MINUTE INTERVALS DURING THE FIRST FIVE MINUTES AFTER THE INJECTION.
(2)TO STIMULATE PANCREATIC SECRETION (ESPECIALLY IN CONJUNCTION WITH SECRETIN) PRIOR TO OBTAINING A DUODENAL ASPIRATE FOR ANALYSIS OF ENZYME ACTIVITY, COMPOSITION, AND CYTOLOGY
FOR THE SECRETIN-KINEVAC TEST OF PANCREATIC FUNCTION, THE PATIENT RECEIVES A DOSE OF 0.25 UNITS SECRETIN PER KG BY INTRAVENOUS INFUSION OVER A 60-MLNUTE PERIOD. THIRTY MINUTES AFTER THE INITIATION OF THE SECRETIN INFUSION, A SEPARATE IV INFUSION OF SINCALIDE AT A TOTAL DOSE OF 0.02 MCG PER KG IS ADMINISTERED OVER A 30-MINUTE INTERVAL. FOR EXAMPLE, THE TOTAL DOSE FOR A 70 KG PATIENT IS 1.4 MCG OF SINCALIDE; THEREFORE, DILUTE 1.4 ML OF RECONSTITUTED SINCALIDE SOLUTION TO 30 ML WITH SODIUM CHLORIDE INJECTION USP AND ADMINISTER AT A RATE OF 1 ML PER MINUTE.
(3) TO ACCELERATE THE TRANSIT OF A BARIUM MEAL THROUGH THE SMALL BOWEL, THEREBY DECREASING THE TIME AND-EXTENT OF RADIATION ASSOCIATED WITH FLUOROSCOPY AND X-RAY EXAMINATION OF THE INTESTINAL TRACT.
TO ACCELERATE THE TRANSIT TIME OF A BARIUM MEAL THROUGH THE SMALL BOWEL, ADMINISTER SINCALIDE AFTER THE BARIUM MEAL IS BEYOND THE PROXIMAL JEJUNUM. (SINCALIDE, LIKE CHOLECYSTOKININ, MAY CAUSE PYLORIC CONTRACTION.) THE RECOMMENDED DOSE IS 0.04 MCG SINCALIDE PER KG (2.8 MCG/70 KG) INJECTED INTRAVENOUSLY OVER A 30- TO 60-SECOND INTERVAL; IF SATISFACTORY TRANSIT OF THE BARIUM MEAL HAS NOT OCCURRED IN 30 MINUTES, A SECOND DOSE OF 0.04 MCG SINCALIDE PER KG MAY BE ADMINISTERED. FOR REDUCTION OF SIDE EFFECTS, A 30-MINUTE IV INFUSION OF SINCALIDE [0.12 MCG PER KG (8.4 MCG/70 KG) DILUTED TO APPROXIMATELY 100 ML WITH SODIUM CHLORIDE INJECTION USP] MAY BE ADMINISTERED.