HISTRELIN ACETATE IS A SYNTHETIC NONAPEPTIDE ANALOG OF THE NATURALLY OCCURRING GONADOTROPIN RELEASING HORMONE (GNRH) THAT POSSESSES A GREATER POTENCY THAN THE NATURAL SEQUENCE HORMONE.
LONG-TERM TREATMENT WITH HISTRELIN ACETATE SUPPRESSES THE LH RESPONSE TO GNRH CAUSING LH LEVELS TO DECREASE TO PREPUBERTAL LEVELS WITHIN 1 MONTH OF TREATMENT. AS A RESULT, SERUM CONCENTRATIONS OF SEX STEROIDS (ESTROGEN OR TESTOSTERONE) ALSO DECREASE. CONSEQUENTLY, SECONDARY SEXUAL DEVELOPMENT CEASES TO PROGRESS IN MOST PATIENTS. ADDITIONALLY, LINEAR GROWTH VELOCITY IS SLOWED WHICH IMPROVES THE CHANCE OF ATTAINING PREDICTED ADULT HEIGHT.