PEMIROLAST POTASSIUM IS A MAST CELL STABILIZER THAT INHIBITS THE IN VIVO TYPE I IMMEDIATE HYPERSENSITIVITY REACTION.
IN VITRO AND IN VIVOSTUDIES HAVE DEMONSTRATED THAT PEMIROLAST POTASSIUM INHIBITS THE ANTIGEN-INDUCED RELEASE OF INFLAMMATORY MEDIATORS (E.G., HISTAMINE, LEUKOTRIENE C4,D4,E4) FROM HUMAN MAST CELLS.
IN ADDITION, PEMIROLAST POTASSIUM INHIBITS THE CHEMOTAXIS OF EOSINOPHILS INTO OCULAR TISSUE AND BLOCKS THE RELEASE OF MEDIATORS FROM HUMAN EOSINOPHILS.
ALTHOUGH THE PRECISE MECHANISM OF ACTION IS UNKNOWN, THE DRUG HAS BEEN REPORTED TO PREVENT CALCIUM INFLUX INTO MAST CELLS UPON ANTIGEN STIMULATION.