PRULIFLOXACIN IS A PRODRUG AND IS RAPIDLY AND EXTENSIVELY METABOLIZED TO ULIFLOXACIN (AFTER ORAL ADMINISTRATION, THERE ARE NO DETECTABLE CONCENTRATIONS OF PRULIFLOXACIN FOUND IN PLASMA). PRULIFLOXACIN IS ACTIVE IN VITRO IN A WIDE NUMBER OF PATHOGENS GRAM-POSITIVE AND GRAM-NEGATIVE. PRULIFLOXACIN EXERTS ITS ANTIBACTERIAL ACTION BY SELECTIVELY INHIBITING THE DNA-GYRASE, AN VITAL ENZYME PRESENT IN BACTERIA, WHICH IS INVOLVED IN DUPLICATION, TRANSCRIPTION AND REPAIR OF DMA.