KETOCONAZOLE APPROXIMATELY DOUBLED PARICALCITOL PLASMA LEVLS. SINCE PARICALCITOL IS PARTIALLY METABOLIZED BY CYP3A AND KETOCONAZOLE IS KNOWN TO BE A STRONG INHIBITOR OF CYTOCHROME P450 3A ENZYME, CARE SHOULD BE TAKEN WHILE DOSING PARICALCITOL WITH KETOCONAZOLE AND OTHER STRONG P450 3A INHIBITORS INCLUDING ATAZANAVIR, CLARITHROMYCIN, INDINAVIR, ITRACONAZOLE, NEFAZODONE, NELFINAVIR, RITONAVIR, SAQUINAVIR, TELITHROMYCIN OR VORICONAZOLE.
DIGITALIS TOXICITY IS POTENTIATED BY HYPERCALCEMIA OF ANY CAUSE, SO CAUTION SHOULD BE APPLIED WHEN DIGITALIS COMPOUNDS ARE PRESCRIBED CONCOMITANTLY WITH PARICALCITOL.