BY INTRAVENOUS INFUSION, ADULT AND CHILD OVER 5 YEARS, 500 MICROGRAMS/KG ONCE WEEKLY .
ADMINISTRATION:
IDURSULFASE SOLUTION IS A CONCENTRATED SOLUTION FOR INTRAVENOUS INFUSION AND MUST BE DILUTED IN 100 ML OF 0.9% SODIUM CHLORIDE INJECTION, USP. USE OF AN INFUSION SET EQUIPPED WITH A 0.2 MICROMETER (?M) FILTER IS RECOMMENDED.
THE TOTAL VOLUME OF INFUSION MAY BE ADMINISTERED OVER A PERIOD OF 1 TO 3 HOURS. PATIENTS MAY REQUIRE LONGER INFUSION TIMES DUE TO INFUSION REACTIONS; HOWEVER, INFUSION TIMES SHOULD NOT EXCEED 8 HOURS. THE INITIAL INFUSION RATE SHOULD BE 8 ML/HR FOR THE FIRST 15 MINUTES. IF THE INFUSION IS WELL TOLERATED, THE RATE MAY BE INCREASED BY 8 ML/HR INCREMENTS AT 15 MINUTE INTERVALS IN ORDER TO ADMINISTER THE FULL VOLUME WITHIN THE DESIRED PERIOD OF TIME. HOWEVER, AT NO TIME SHOULD THE INFUSION RATE EXCEED 100 ML/HR.