THE RECOMMENDED INITIAL DOSE OF RALTITREXED IN PATIENTS WITH NORMAL RENAL FUNCTION IS 3 MG/M2 GIVEN BY IV INF OVER 15 MIN. SUBSEQUENT DOSES, WHICH SHOULD BE REDUCED BY UP TO 50% DEPENDING ON THE SEVERITY OF INITIAL TOXICITY, MAY BE GIVEN AT INTERVALS OF 3 WKS PROVIDED TOXICITY HAS RESOLVED.
IN RENAL IMPAIRMENT:
DOSAGE INTERVAL SHOULD BE INCREASED FROM 3 TO 4 WEEKS AND THE DOSE ADJUSTED ON THE BASIS OF CREATININE CLEARANCE (CC) AS FOLLOWS:
CC OF 55 TO 65 ML/MINUTE, 2.25 MG/M2
CC OF 25 TO 54 ML/MINUTE, 1.5 MG/M2
CC LESS THAN 25 ML/MINUTE, TREATMENT CONTRA-INDICATED