IT IS POSSIBLE THAT DRUGS THAT INHIBIT REPLICATION OF RAPIDLY DIVIDING CELL POPULATIONS SUCH AS BONE MARROW,SPERMATOGONIA AND GERMINAL LAYERS OF SKIN AND GASTROINTESTINAL MUCOSA MAY HAVE ADDITIVE TOXICITY WHEN ADMINISTERED CONCOMITANTLY WITH VALGANCICLOVIR. THEREFORE, DRUGS SUCH AS DAPSONE, PENTAMIDINE, FLUCYTOSINE, VINCRISTINE, VINBLASTINE, ADRIAMYCIN, AMPHOTERICIN B, TRIMETHOPRIM/SULFAMETHOXAZOLE COMBINATIONS OR OTHER NUCLEOSIDE ANALOGUES, SHOULD BE CONSIDERED FOR CONCOMITANT USE WITH VANGANCICLOVIR ONLY IF THE POTENTIAL BENEFITS ARE JUDGED TO OUTWEIGH THE RISKS.
GENERALIZED SEIZURES HAVE BEEN REPORTED IN PATIENTS WHO RECEIVED VANGANCICLOVIR AND IMIPENEM-CILASTATIN. RENAL CLEARANCE OF VANGANCICLOVIR DECREASED WITH PROBENECID.