RESTLESS LEGS SYNDROME:
INITIALLY 250 MICROGRAMS AT NIGHT FOR 2 DAYS, INCREASED IF TOLERATED TO 500 MICROGRAMS AT NIGHT FOR 5 DAYS AND THEN TO 1 MG AT NIGHT FOR 7 DAYS; FURTHER INCREASED AT WEEKLY INTERVALS IN STEPS OF 500 MICROGRAMS DAILY ACCORDING TO RESPONSE; USUAL DOSE 2 MG ONCE DAILY AT NIGHT; MAX. 4 MG ONCE DAILY; CHILD AND ADOLESCENT UNDER 18 YEARS NOT RECOMMENDED
NOTE REPEAT DOSE TITRATION IF RESTARTING AFTER INTERVAL OF MORE THAN A FEW DAYS
THE SCOTTISH MEDICINES CONSORTIUM HAS ADVISED (JUNE 2006) THAT ROPINIROLE SHOULD BE RESTRICTED FOR USE IN PATIENTS WITH A BASELINE SCORE OF 24 POINTS OR MORE ON THE INTERNATIONAL RESTLESS LEGS SCALE
PARKINSONISM:
STARTING DOSE FOR PARKINSON'S DISEASE IS 0.25 MG 3 TIMES DAILY. BASED ON INDIVIDUAL PATIENT RESPONSE, DOSAGE SHOULD THEN BE TITRATED WITH WEEKLY INCREMENTS BY 0.25 MG UP TO 1 MG TDS. AFTER WEEK 4, IF NECESSARY, DAILY DOSAGE MAY BE INCREASED BY 1.5 MG/DAY ON A WEEKLY BASIS UP TO A DOSE OF 9 MG/DAY, AND THEN BY UP TO 3 MG/DAY WEEKLY TO A TOTAL DOSE OF 24 MG/DAY. DOSES GREATER THAN 24 MG/DAY HAVE NOT BEEN TESTED.
WHEN ROPINIROLE IS GIVEN AS ADJUNCT THERAPY TO L-DOPA, THE CONCURRENT DOSE OF L-DOPA MAY BE REDUCED GRADUALLY UPTO 31%.