BY SUBCUTANEOUS INJECTION, USUAL RANGE (AFTER INITIATION AS BELOW) 3 - 30 MG DAILY IN DIVIDED DOSES; SUBCUTANEOUS INFUSION MAY BE PREFERABLE IN THOSE REQUIRING DIVISION OF INJECTIONS INTO MORE THAN 10 DOSES DAILY; MAX. SINGLE DOSE 10 MG; CHILD AND ADOLESCENT UNDER 18 YEARS NOT RECOMMENDED
BY CONTINUOUS SUBCUTANEOUS INFUSION (THOSE REQUIRING DIVISION INTO MORE THAN 10 INJECTIONS DAILY) INITIALLY 1 MG/HOUR DAILY INCREASED ACCORDING TO RESPONSE (NOT MORE OFTEN THAN EVERY 4 HOURS) IN MAX. STEPS OF 500 MICROGRAMS/HOUR, TO USUAL RATE OF 1 - 4 MG/HOUR (14 - 60 MICROGRAMS/KG/HOUR); CHANGE INFUSION SITE EVERY 12 HOURS AND GIVE DURING WAKING HOURS ONLY (24-HOUR INFUSIONS NOT ADVISED UNLESS SEVERE NIGHT-TIME SYMPTOMS) INTERMITTENT BOLUS BOOSTS ALSO USUALLY NEEDED; CHILD AND ADOLESCENT UNDER 18 YEARS NOT RECOMMENDED
NOTE TOTAL DAILY DOSE BY EITHER ROUTE (OR COMBINED ROUTES) MAX. 100 MG
REQUIREMENTS FOR INITIATION HOSPITAL ADMISSION AND AT LEAST 2 DAYS OF PRETREATMENT WITH DOMPERIDONE FOR NAUSEA AND VOMITING, AFTER AT LEAST 3 DAYS WITHHOLD EXISTING ANTIPARKINSONIAN MEDICATION OVERNIGHT TO PROVOKE βOFF' EPISODE, DETERMINE THRESHOLD DOSE, RE-ESTABLISH OTHER ANTIPARKINSONIAN DRUGS, DETERMINE EFFECTIVE APOMORPHINE REGIMEN, TEACH TO ADMINISTER BY SUBCUTANEOUS INJECTION INTO LOWER ABDOMEN OR OUTER THIGH AT FIRST SIGN OF βOFF' EPISODE, DISCHARGE FROM HOSPITAL, MONITOR FREQUENTLY AND ADJUST DOSAGE REGIMEN AS APPROPRIATE (DOMPERIDONE MAY NORMALLY BE WITHDRAWN OVER SEVERAL WEEKS OR LONGER).
ERECTILE DYSFUNCTION: THE USUAL INITIAL DOSE IS 2Β MG TAKEN SUBLINGUALLY ABOUT 20 MINUTES BEFORE SEXUAL ACTIVITY. A DOSE OF 3Β MG MAY BE USED ON SUBSEQUENT OCCASIONS IF NECESSARY BUT A MINIMUM OF 8 HOURS SHOULD BE ALLOWED BETWEEN DOSES.