CONCURRENT USE OF OTHER ANTIDEPRESSANTS-MAOIS, SSRIS, SNRIS AND TRICYCLIC ANTIDEPRESSANTS-CAN CAUSE SEROTONIN SYNDROME, A VERY SERIOUS AND SOMETIMES FATAL TOXICITY SYNDROME. DEXTROMETHORPHAN (COUGH MEDICINE) AND MDMA (ECSTASY) CAN ALSO CAUSE SEROTONIN SYNDROME IF YOU ARE TAKING MECLOBEMIDE. EPHEDRINE, PSEUDOEPHEDRINE AND SIMILAR DRUGS CAN CAUSE A SEVERE HYPERTENSIVE CRISIS WHEN TAKEN WITH MECLOBEMIDE. THESE MEDICATIONS ARE OFTEN FOUND IN OVER-THE-COUNTER COLD, ALLERGY AND WEIGHT LOSS MEDICATIONS. THEY CAN BE FOUND IN HERBAL TEAS, TOO. AMPHETAMINE AND METHAMPHETAMINE CAN ALSO CAUSE SEVERE HYPERTENSION. CIMETADINE (TAGAMET) INCREASES THE EFFECT OF MECLOBEMIDE AND A REDUCED DOSE IS NECESSARY. MECLOBEMIDE CAUSES BENZODIAZEPINES (TRANQUILIZERS) TO ACCUMULATE; THE DOSAGE OF THE TRANQUILIZER MAY NEED TO BE DECREASED. MECLOBEMIDE INTERACTS WITH ANESTHETICS AND SHOULD BE STOPPED 48 HOURS BEFORE ANY ELECTIVE SURGERY. YOU CAN START TAKING IT AGAIN 24 HOURS AFTER SURGERY. SERIOUS INTERACTIONS CAN OCCUR BETWEEN MECLOBEMIDE AND THORIDAZINE (MELLARIL) OR MEPERDINE (DEMEROL).