Name
ZOTEPINE
Mode of Action
CLOZAPINE ACTS BY BLOCKING DOPAMINE RECEPTORS IN CNS AND IT HAS SOME CHOLINERGIC, ADRENERGIC, HISTAMINERGIC, SEROTONERGIC BLOCKING ACTIVITY.
Dosage
INITIALLY 25 MG 3 TIMES DAILY INCREASED ACCORDING TO RESPONSE AT INTERVALS OF 4 DAYS TO MAX. 100 MG 3 TIMES DAILY; ELDERLY INITIALLY 25 MG TWICE DAILY INCREASED ACCORDING TO RESPONSE TO MAX. 75 MG TWICE DAILY; CHILD AND ADOLESCENT UNDER 18 YEARS NOT RECOMMENDED
Drug Group
[ANTIPSYCHOTIC] , [URICOSURIC]
Cross Reaction
ZOTEPINE MAY ENHANCE THE EFFECTS OF OTHER CNS DEPRESSANTS AND ANTIMUSCARINICS. THE RISK OF SEIZURES IS PARTICULARLY INCREASED WHEN ZOTEPINE IS GIVEN WITH HIGH DOSES OF OTHER ANTIPSYCHOTICS AND THE COMBINATION IS NOT RECOMMENDED. ADDITIVE HYPOTENSIVE EFFECTS MAY THEORETICALLY OCCUR WITH ANTIHYPERTENSIVES AND SOME ANAESTHETIC DRUGS; HOWEVER ITS ?-BLOCKING ACTIONS MIGHT REDUCE THE EFFECTS OF METHYLDOPA OR CLONIDINE. THE RISK OF ARRHYTHMIAS WITH ZOTEPINE MAY BE INCREASED BY USE WITH OTHER DRUGS THAT PROLONG THE QT INTERVAL OR CAUSE HYPOKALAEMIA. USE OF ZOTEPINE WITH FLUOXETINE OR DIAZEPAM MAY LEAD TO INCREASED PLASMA CONCENTRATIONS OF ZOTEPINE.
Drug Interaction
Drugs Side Effect
Drug Categories
Special Precaution
Drug Safety
Monograph