IMMUNOTHERAPY USING ALLERGEN VACCINES CONTAINING HOUSE DUST MITE, ANIMAL DANDER (CAT OR DOG), OR EXTRACTS OF GRASS AND TREE POLLEN CAN REDUCE SYMPTOMS OF ASTHMA AND ALLERGIC RHINOCONJUNCTIVITIS. A VACCINE CONTAINING EXTRACTS OF WASP AND BEE VENOM IS USED TO REDUCE THE RISK OF SEVERE ANAPHYLAXIS AND SYSTEMIC REACTIONS IN INDIVIDUALS WITH HYPERSENSITIVITY TO WASP AND BEE STINGS. DESENSITISING VACCINES SHOULD BE AVOIDED IN PREGNANT WOMEN, IN CHILDREN UNDER FIVE YEARS OLD, AND IN THOSE TAKING BETA-BLOCKERS (ADRENALINE MAY BE INEFFECTIVE IN CASE OF A HYPERSENSITIVITY REACTION), OR ACE INHIBITORS (RISK OF SEVERE ANAPHYLACTOID REACTIONS).