CIMETIDINE INCREASED THE PLASMA LEVELS OF NISOLDIPINE ALTHOUGH RANITIDINE DID NOT HAVE ANY EFFECT. PHENYTOIN, CARBAMAZEPINE, PHENOBARBITONES & OTHER CYP3A4 INDUCERS REDUCED THE PLASMA LEVELS OF THE DRUG DUE TO INCREASED METABOLISM. IT MAY ELEVATE SERUM CONC. OF DIGOXIN SO CARE SHOULD BE TAKEN FOR DIGOXIN TOXICITY. MAY EFFECT GLUCOSE LEVELS IN DIABETICS. ITRACONAZOLE, FLUCONAZOLE, CYCLOSPORIN REDUCE ITS METABOLISM. CONCURRENT USE WITH MAGNESIUM SALTS MAY CAUSE PROFOUND HYPOTENSION OR NEUROMUSCULAR BLOCK.
THE DEPRESSION OF CARDIAC CONTRACTILITY, CONDUCTIVITY, AND AUTOMATICITY, AS WELL AS THE VASCULAR DILATION ASSOCIATED WITH ANESTHETICS, MAY BE POTENTIATED BY CALCIUM CHANNEL BLOCKERS. WHEN USED CONCOMITANTLY, ANESTHETICS AND CALCIUM BLOCKERS SHOULD BE TITRATED CAREFULLY. . CONCURRENT USED WITH OTHER CARDIAC DEPRESSANTS SUCH AS AMIODARONE, BETA BLOCKERS, DIGOXIN, AND MEFLOQUINE THERE MAY BE RISK OF BRADYCARDIA AND ATRIOVENTRICULAR BLOCK.