IN HYPOGLYCAEMIA, THE INITIAL DOSE IS 3 TO 5 MG/KG DAILY IN 2 OR 3 DIVIDED DOSES BY MOUTH, THEN ADJUSTED ACCORDING TO RESPONSE. USUAL MAINTENANCE DOSES ARE FROM 3 TO 8 MG/KG DAILY BUT TOTAL DOSES OF UP TO 1 G DAILY HAVE BEEN GIVEN TO ADULTS WITH INSULINOMAS (). IN NEONATES THE INITIAL DOSE IS 5 MG/KG TWICE DAILY; USUAL MAINTENANCE DOSES RANGE FROM 3 TO 9 MG/KG DAILY, ALTHOUGH UP TO 21 MG/KG DAILY MAY BE REQUIRED. IN CHILDREN FROM 1 MONTH OF AGE, THE INITIAL DOSE IS 1.7 MG/KG THREE TIMES DAILY, AND THE USUAL MAINTENANCE DOSES ARE AS FOR NEONATES; UP TO 15 MG/KG DAILY MAY BE REQUIRED. THE HYPERGLYCAEMIC EFFECT NORMALLY BEGINS WITHIN 1 HOUR OF ADMINISTRATION AND LASTS FOR UP TO 8 HOURS. THE DOSES FOR NEONATES AND CHILDREN MAY BE GIVEN INTRAVENOUSLY IF NECESSARY.
IN HYPERTENSIVE CRISES, A BOLUS INTRAVENOUS INJECTION OF 1 TO 3 MG/KG IS GIVEN WITHIN 30 SECONDS, UP TO A MAXIMUM DOSE OF 150 MG, AND REPEATED AFTER 5 TO 15 MINUTES IF REQUIRED.