CO-ADMINISTRATION OF THE CYP3A4 SUBSTRATES, TERFENADINE, ASTEMIZOLE, CISAPRIDE, PIMOZIDE OR QUINIDINE, ALONG WITH VORICONAZOLE ARE CONTRAINDICATED SINCE INCREASED PLASMA CONCENTRATIONS OF THESE DRUGS CAN LEAD TO QTC PROLONGATION AND RARE OCCURRENCES OF TORSADES DE POINTES.
CO-ADMINISTRATION OF VORICONAZOLE WITH RIFAMPICIN, CARBAMAZEPINE AND PHENOBARBITAL IS CONTRAINDICATED SINCE THESE MEDICINAL PRODUCTS ARE LIKELY TO DECREASE PLASMA VORICONAZOLE CONCENTRATIONS SIGNIFICANTLY.
CO-ADMINISTRATION OF VORICONAZOLE WITH RITONAVIR (400 MG Q12H) IS CONTRAINDICATED BECAUSE RITONAVIR SIGNIFICANTLY DECREASES PLASMA VORICONAZOLE CONCENTRATIONS IN HEALTHY SUBJECTS.
CO - ADMINISTRATION OF VORICONAZOLE WITH SIROLIMUS IS CONTRAINDICATED BECAUSE VORICONAZOLE SIGNIFICANTLY INCREASES SIROLIMUS CONCENTRATIONS IN HEALTHY SUBJECTS.
CO-ADMINISTRATION OF VORICONAZOLE WITH EFAVIRENZ IS CONTRAINDICATED BECAUSE EFAVIRENZ SIGNIFICANTLY DECREASES PLASMA VORICONAZOLE CONCENTRATIONS WHILE VORICONAZOLE ALSO SIGNIFICANTLY INCREASES EFAVIRNEZ PLASMA CONCENTRATIONS. EFAVIRENZ MAY BE CO-ADMINISTERED WITH VORICONAZOLE IF THE MAINTENANCE DOSE OF VORICONAZOLE IS INCREASED TO 400 MG EVERY 12 HOURS AND THE EFAVIRENZ DOSE IS REDUCED BY 50%, I.E. TO 300 MG ONCE DAILY. WHEN TREATMENT WITH VORICONAZOLE IS STOPPED, THE INITIAL DOSAGE OF EFAVIRENZ SHOULD BE RESTORED
THE CONCOMITANT USE OF VORICONAZOLE WITH ST. JOHN`S WORT IS CONTRAINDICATED.
CO-ADMINISTRATION OF ERGOT ALKALOIDS (ERGOTAMINE, DIHYDROERGOTAMINE), WHICH ARE CYP3A4 SUBSTRATES, IS CONTRAINDICATED SINCE INCREASED PLASMA CONCENTRATIONS OF THESE MEDICINAL PRODUCTS CAN LEAD TO ERGOTISM.
PHENYTOIN MAY BE CO-ADMINISTERED WITH VORICONAZOLE IF THE MAINTENANCE DOSE OF VORICONAZOLE IS INCREASED FROM 200 MG TO 400 MG ORALLY, TWICE DAILY (100 MG TO 200 MG ORALLY, TWICE DAILY IN PATIENTS LESS THAN 40 KG).
RIFABUTIN MAY BE CO-ADMINISTERED WITH VORICONAZOLE IF THE MAINTENANCE DOSE OF VORICONAZOLE IS INCREASED FROM 200 MG TO 350 MG ORALLY, TWICE DAILY(100 MG TO 200 MG ORALLY, TWICE DAILY IN PATIENTS LESS THAN 40 KG)