RUPATADINE DISPLAYS STRONG ANTAGONIST ACTIVITY TOWARDS BOTH HISTAMINE H1 RECEPTORS AND PAF RECEPTORS. IN ADDITION, RUPATADINE HAS A PROFILE AS AN ANTIALLERGIC DRUG WITH POTENTIALLY BENEFICIAL EFFECTS, SUCH AS INHIBITION OF MAST CELL DEGRANULATION, NEUTROPHIL AND EOSINOPHIL MIGRATION AND CYTOKINE RELEASE. RUPATADINE HAS HIGH AFFINITY FOR THE HISTAMINE H1 RECEPTOR. RUPATADINE PROVED TO BE MORE ACTIVE THAN TERFENADINE, LORATADINE, CETIRIZINE, HYDROXYZINE AND DIPHENHYDRAMINE.