THE MAXIMUM RECOMMENDED DOSE OF ZOMETA IN HYPERCALCEMIA OF MALIGNANCY (ALBUMIN-CORRECTED SERUM CALCIUM * >/=12 MG/DL [3.0 MMOL/L]) IS 4 MG. THE 4-MG DOSE MUST BE GIVEN AS A SINGLE-DOSE INTRAVENOUS INFUSION OVER NO LESS THAN 15 MINUTES.
PATIENTS SHOULD BE ADEQUATELY REHYDRATED PRIOR TO ADMINISTRATION OF ZOMETA.
RETREATMENT WITH ZOMETA 4 MG, MAY BE CONSIDERED IF SERUM CALCIUM DOES NOT RETURN TO NORMAL OR REMAIN NORMAL AFTER INITIAL TREATMENT. IT IS RECOMMENDED THAT A MINIMUM OF 7 DAYS ELAPSE BEFORE RETREATMENT, TO ALLOW FOR FULL RESPONSE TO THE INITIAL DOSE.
STANDARD HYPERCALCEMIA-RELATED METABOLIC PARAMETERS, SUCH AS SERUM LEVELS OF CALCIUM, PHOSPHATE, AND MAGNESIUM, AS WELL AS SERUM CREATININE, SHOULD BE CAREFULLY MONITORED FOLLOWING INITIATION OF THERAPY WITH ZOMETA
IV INF -TREATMENT OF PAGET'S DISEASE OF BONE, BY INTRAVENOUS INFUSION, 5 MG AS A SINGLE DOSE OVER AT LEAST 15 MINUTES.