IN VITRO, OXALIPLATIN WAS NOT DISPLACED FROM PLASMA PROTEINS BY THE FOLLOWING MEDICATIONS: ERYTHROMYCIN, SALICYLATE, SODIUM VALPROATE, GRANISETRON, AND PACLITAXEL. IN VITRO, OXALIPLATIN IS NOT METABOLIZED BY, NOR DOES IT INHIBIT, HUMAN CYTOCHROME P450 ISOENZYMES. NO P450-MEDIATED DRUG-DRUG INTERACTIONS ARE THEREFORE ANTICIPATED IN PATIENTS.