DEPRESSANT EFFECTS OF MORPHINE ARE POTENTIATED BY CONCOMITANT ADMINISTRATION OR IN THE PRESENCE OF OTHER CNS DEPRESSANTS SUCH AS ALCOHOL, SEDATIVES, ANTIHISTAMINICS, BENZODIAZEPINES LIKE ALPRAZOLAM OR PSYCHOTROPIC DRUGS (MAO INHIBITORS, PHENOTHIAZINES, BUTYROPHENONES AND TRICYCLIC ANTIDEPRESSANTS). PREMEDICATION OR INTRA-ANESTHETIC USE OF NEUROLEPTIC WITH IT MAY INCREASE THE RISK OF RESPIRATORY DEPRESSION.