DOSES ARE RECONSTITUTED IN SODIUM CHLORIDE 0.9% INJECTION. THE CONCENTRATION OF THE INFUSION SOLUTION SHOULD NOT EXCEED THE EQUIVALENT OF 40 MG OF GEMCITABINE PER ML. THE RECOMMENDED INITIAL DOSE IS THE EQUIVALENT OF I G OF GEMCITABINE PER SQ.M BODYSURFACE, BY INFUSION OVER 30 MINUTES. THE DOSE MAY BE REPEATED AT WEEKLY INTERVALS ADJUSTED ACCORDING TO RESPONSE AND TOXICITY.
PANCREATIC CANCER:1 G/M2 ONCE WEEKLY FOR UP TO 7 WEEKS MAY BE GIVEN, FOLLOWED AFTER A ONE-WEEK RECOVERY PERIOD BY A REGIMEN OF INFUSIONS ONCE WEEKLY FOR 3 CONSECUTIVE WEEKS OUT OF 4.
NON-SMALL CELL LUNG CANCER: GEMCITABINE MAY BE GIVEN AS A SINGLE AGENT; 1 G/M2 ONCE WEEKLY FOR 3 CONSECUTIVE WEEKS OUT OF 4 IS RECOMMENDED. ALTERNATIVELY, IT MAY BE GIVEN BEFORE CISPLATIN. TWO SCHEDULES HAVE BEEN USED; GEMCITABINE 1.25 G/M2 IS GIVEN ON DAYS 1 AND 8 OF A 21-DAY CYCLE, OR GEMCITABINE 1 G/M2 IS GIVEN ON DAYS 1, 8 AND 15 OF A 28-DAY CYCLE.
BLADDER CANCER: GEMCITABINE IS GIVEN BEFORE CISPLATIN. THE RECOMMENDED DOSE OF GEMCITABINE IS 1 G/M2 ON DAYS 1, 8, AND 15 OF A 28-DAY CYCLE.
BREAST CANCER: GEMCITABINE IS USUALLY GIVEN AFTER A TAXANE SUCH AS PACLITAXEL. A DOSE OF GEMCITABINE 1.25 G/M2 IS GIVEN ON DAYS 1 AND 8 OF A 21-DAY CYCLE.