THE USUAL DOSE :- 0.3 TO 0.4 MG/KG/BODY WT. AT 1-4 WEEKS INTERVALS.
BLADDER CANCER THIOTEPA IN DOSES UP TO 60 MG MAY BE INSTILLED IN 30 TO 60 ML OF STERILE WATER OR SODIUM CHLORIDE 0.9% INTO THE BLADDER OF A PATIENT PREVIOUSLY DEHYDRATED FOR 8 TO 12 HOURS, AND RETAINED IF POSSIBLE FOR 2 HOURS. THE INSTILLATION MAY BE REPEATED WEEKLY FOR UP TO 4 WEEKS. SIMILAR INSTILLATIONS HAVE BEEN GIVEN AT INTERVALS OF 1 TO 2 WEEKS, FOR UP TO 8 INSTILLATIONS IN THE PROPHYLAXIS OF RECURRENCE AFTER SURGICAL REMOVAL OF BLADDER CANCER. SINGLE DOSES OF 90 MG IN 100 ML OF STERILE WATER HAVE ALSO BEEN USED PROPHYLACTICALLY. FOR MALIGNANT EFFUSIONS, DOSES OF UP TO 60 MG OF THIOTEPA IN 20 TO 60 ML OF STERILE WATER MAY BE INSTILLED AFTER ASPIRATION; IN THE USA THE LICENSED DOSE IS 600 TO 800 MICROGRAMS/KG, A DOSE SIMILAR TO THAT SUGGESTED FOR INJECTION DIRECTLY INTO TUMOURS. THIOTEPA FOR LOCAL USE MAY BE MIXED WITH SOLUTIONS OF PROCAINE AND ADRENALINE.
INTRAMUSCULAR AND INTRAVENOUS DOSAGE REGIMENS VARY CONSIDERABLY; SEVERAL REGIMENS HAVE USED COURSES OF 15 MG DAILY FOR 4 DAYS. IN THE USA A LICENSED DOSE IS 300 TO 400 MICROGRAMS/KG GIVEN AT 1- TO 4-WEEK INTERVALS. A SOLUTION CONTAINING 1 MG/ML IN STERILE WATER HAS BEEN TRIED INTRATHECALLY IN DOSES OF UP TO 10 MG GIVEN ON ALTERNATE DAYS, FOR UP TO 4 DOSES.
PTERYGIUM : THIOTEPA 0.05% IN STERILE RINGER'S SOLUTION HAS BEEN INSTILLED AS EYE DROPS EVERY 3 HOURS FOR UP TO 6 WEEKS FOLLOWING SURGICAL REMOVAL OF PTERYGIUM IN ORDER TO REDUCE THE LIKELIHOOD OF RECURRENCE.
CONDYLOMATA ACUMINATA : 60 MG WEEKLY HAS BEEN INSTILLED INTO THE URETHRA FOR THE TREATMENT OF CONDYLOMATA ACUMINATA (GENITAL WARTS). TOPICAL APPLICATION OF THIOTEPA HAS ALSO BEEN USED FOR CONDYLOMATA.