PLASMINOGEN ACTIVATORS ARE SUBSTANCES THAT CONVERT FIBRIN BOUND PLASMINOGEN TO ACTIVE FORM PLASMIN, RESULTING IN FIBRINOLYSIS AND DISSOLUTION OF CLOT. THESE CAN BE PRODUCED BY RECOMBINANT DNA TECHNOLOGY OR CAN BE EXTRACTED FROM BODY TISSUES. STREPTOKINASE, ALTEPLASE, UROKINASE ARE SOME OF PLASMINOGEN ACTIVATORS USED IN MEDICAL THERAPEUTICS.