USE OF VOLATILE INHALATIONAL ANESTHETICS SUCH AS ENFLURANE, ISOFLURANE, DESFLURANE, SEVOFLURANE AND HALOTHANE WITH PANCURONIUM WILL ENHANCE NEUROMUSCULAR BLOCKADE.
PRIOR ADMINISTRATION OF SUCCINYLCHOLINE MAY ENHANCE THE NEUROMUSCULAR BLOCKING EFFECT OF PANCURONIUM AND INCREASE ITS DURATION OF ACTION.
PANCURONIUM SHOULD BE GIVEN WITH CAUTION TO PATIENTS RECEIVING CHRONIC TRICYCLIC ANTIDEPRESSANT THERAPY WHO ARE ANESTHETIZED WITH HALOTHANE BECAUSE SEVERE VENTRICULAR ARRHYTHMIAS MAY RESULT FROM THIS COMBINATION. AMINOGLYCOSIDES (SUCH AS NEOMYCIN, STREPTOMYCIN, KANAMYCIN, GENTAMICIN, AND DIHYDROSTREPTOMYCIN); TETRACYCLINES; BACITRACIN; POLYMYXIN B; COLISTIN; AND SODIUM COLISTIMETHATE. IF THESE OR OTHER NEWLY INTRODUCED ANTIBIOTICS ARE USED PREOPERATIVELY OR IN CONJUNCTION WITH PANCURONIUM, UNEXPECTED PROLONGATION OF NEUROMUSCULAR BLOCK SHOULD BE CONSIDERED A POSSIBILITY. INJECTION OF QUINIDINE DURING RECOVERY FROM USE OF OTHER MUSCLE RELAXANTS SUGGESTS THAT RECURRENT PARALYSIS MAY OCCUR. MAGNESIUM SALTS, ADMINISTERED FOR THE MANAGEMENT OF TOXEMIA OR PREGNANCY, MAY ENHANCE THE NEUROMUSCULAR BLOCKADE.
ADMINISTRATION IN PATIENTS RECEIVING CARBAMAZEPINE OR PHENYTOIN MAY HAVE SHORTER DURATION OF NEUROMUSCULAR BLOCK.