PRIMARY CARNITINE DEFICIENCY :- 200 MG/KG DAILY 2 TO 4 DIVIDED DOSES. MAXIMUM :- 400 MG/KG DAILY. 100 MG/KG DAILY 3 TO 4 DIVIDED DOSES BY SLOW I.V. INJECTION.
IN THE UK, DEPENDING ON THE CONDITION, UP TO 200 MG/KG DAILY OF LEVOCARNITINE IS GIVEN BY MOUTH, IN 2 TO 4 DIVIDED DOSES. RARELY, HIGHER DOSES OF UP TO 400 MG/KG DAILY MAY BE NEEDED. IN THE USA, LOWER DOSES OF ABOUT 2 TO 3 G DAILY ARE RECOMMENDED FOR ADULTS; THE DOSE GIVEN FOR INFANTS AND CHILDREN IS 50 TO 100 MG/KG DAILY IN DIVIDED DOSES, TO A MAXIMUM OF 3 G DAILY.
WHEN GIVEN INTRAVENOUSLY, UP TO 100 MG/KG DAILY IS GIVEN IN 3 TO 4 DIVIDED DOSES BY SLOW INTRAVENOUS INJECTION OVER 2 TO 3 MINUTES. HIGHER INTRAVENOUS DOSES HAVE BEEN GIVEN, BUT ARE ASSOCIATED WITH AN INCREASED INCIDENCE OF ADVERSE EFFECTS.
IN PATIENTS WITH CARNITINE DEFICIENCY SECONDARY TO HAEMODIALYSIS, THE RECOMMENDED DOSE OF LEVOCARNITINE IS 10 TO 20 MG/KG INTRAVENOUSLY AFTER EACH DIALYSIS SESSION, ADJUSTED ACCORDING TO PLASMA-CARNITINE CONCENTRATIONS. A MAINTENANCE DOSE OF 1 G DAILY BY MOUTH MAY BE CONSIDERED .