Name
ETIDRONATE DISODIUM
Mode of Action
IT IS THE DISODIUM SALT OF DIPHOSPHORIC ACID. IT ACTS PRIMARLLY ON BONE AND CAN INHIBIT THE FORMATION, GROWTH AND DISSOLUTION OF HYDROXYAPATITE CRYSTALS AND THEIR AMORPHOUS PRECURSORS BY CHEMISORPTION TO CALCIUM PHOSPHATE SURFACES. INHIBITION OF CRYSTAL RESORPTION OCCURS AT LOWER DOSES THAN ARE REQUIRED TO INHIBIT CRYSTAL GROWTH. BOTH EFFECTS INCREASE AS THE DOSE INCREASES. DRONATE OS THERAPY DOES NOT ADVERSELY AFFECT SERUM LEVELS OF PARATHYROID HORMONE OR CALCIUM.
Dosage
PAGETS DISEASE :- THE USUAL INITIAL DOSE :- 5MG/KG/BODY WT.DAILY FOR 6 MONTHS. SEVERE CASES :- 10 MG/KG DAILY. FOR 3 MONTHS. MAXIMUM :- 20 MG/KG DAILY. HYPERCALCAEMIA OF MALIGNANCY :- 7.5 MG/KG/BODY WT DAILY FOR 3 SUCCESSIVE DAYS BY I.V. INFUSION. ( ALSO SEE LIT ).
Drug Group
[BISPHOSPHONATE] , [BONE REGENERATOR]
Cross Reaction
ALUMINIUM, CALCIUM, IRON, OR ANTACIDS CAN IMPAIR THE ABSORPTION OF EITDRONATE DISODIUM. WARFARIN EFFECT WAS POTENTIATED ON CONCURRENT USE.
Drug Interaction
Drugs Side Effect
Drug Categories
Special Precaution
Drug Safety
Monograph