IT IS SELECTIVE, HIGH AFFINITY SEROTONIN (5-HT 4) RECEPTOR AGONIST WITH ENTEROKINETIC ACTIVITIES. IT ALTERS COLONIC MOTILITY PATTERNS & STIMULATES COLONIC MASS MOVEMENTS.
PRUCALOPRIDE ACTS AS A SELECTIVE STIMULATOR OF THE 5-HT4 RECEPTORS WHILE HAVING NO INTERACTION WITH HERG CHANNEL OR 5-HT1 RECEPTORS WHICH REDUCES SIGNIFICANTLY THE CARDIOVASCULAR RISK FOUND IN OTHER SIMILAR DRUGS.
. ITS ACTIVATION PRODUCES THE RELEASE OF ACETYLCHOLINE WHICH IS THE MAJOR EXCITATORY NEUROTRANSMITTER IN THE GI TRACT.2
HENCE, PRUCALOPRIDE STIMULATES MOTILITY BY INTERACTING SPECIFICALLY WITH 5-HT4 RECEPTORS IN THE GI TRACT WHICH CAUSES A RELEASE OF ACETYLCHOLINE AND FURTHER CONTRACTION OF THE MUSCLE LAYER OF THE COLON AND RELAXATION OF THE CIRCULAR MUSCLE LAYER LEADING TO THE PROPULSION OF LUMINAL CONTENT.