MIPOMERSEN SODIUM IS AN OLIGONUCLEOTIDE INHIBITOR OF APO B-100 SYNTHESIS. APOB IS THE PRINCIPAL APOLIPOPROTE IN OF LDL AND ITS METABOLIC PRECURSOR, VERY LOW DENSITY LIPOPROTEIN (VLDL). MIPOMERSEN INHIBITS SYNTHESIS OF APOB BY SEQUENCE-SPECIFIC BINDING TO ITS MESSENGER RIBONUCLEIC ACID (MRNA) RESULTING IN DEGRADATION OF THE MRNA THROUGH ENZYME-MEDIATED PATHWAYS OR DISRUPTION OF MRNA FUNCTION THROUGH BINDING ALONE.